The Congress Opened with A Session on Basic Research 1, 2005-06-15
Friday, 17 June 2005
Moderators: Drs. D. Wilcox and L. Baskin
Dr. Oswald from Innsbruck, Austria presented Abst. 1, "Muscle development of the fetal interureteric junction and the internal vesical sphincter." They studied the fetal development of the interureteric muscle in 38 specimens with a mean gestational age of 16.4 weeks. Histological studies show that there is a close relationship between interureteric muscle of the trigone and vesical sphincter development. This work highlights the interplay between proper development of the sphincter and function of the vesico-ureteric junction. Understanding the embryology will ultimately lead to conquering entities such as reflux and voiding dysfunction.
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ESPU/AAP Section on Urology, 2005-06-16
Friday, 17 June 2005
The first section of the day was lower urinary tract chaired by U. Sillén and B. Kaplan.
The session began with Abst. 58 which showed that acetylcholine acts as a mitogen for human bladder smooth muscle cells. This effect is most pronounced at hydrostatic pressures known to increase muscarinic receptor expression. Also, it was shown that muscarinic receptor inhibition results in a profound decrease in human bladder smooth muscle cell growth. This data suggests that anti-muscarinic drugs may prove beneficial in inhibiting long-term bladder injury observed in bladder outlet obstruction and neurogenic bladders.
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