AUA 2008 - Take Home Message – Bladder Cancer
Wednesday, 28 May 2008
ORLANDO, FL (UroToday.com) - Abstract 1791 showed the importance of a repeat TURBT for T1 grade 3 tumors.
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AUA 2008 - The Natural History of Bladder Carcinoma In Situ after Initial Response to Bacillus Calmete-Gúerin Immunotherapy
Friday, 23 May 2008
ORLANDO, FL (UroToday.com) -
The authors explored patterns of recurrence, muscle invasion, and disease specific mortality in patients with bladder carcinoma in situ (CIS) who responded to an induction course with intravesical BCG immunotherapy.
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AUA 2008 - Does Hydronephrosis on Preoperative Axial CT Imaging Predict Worse Outcomes for Patients Undergoing Nephrouretectomy for Upper-Tract Urothelial Carcinoma?
Tuesday, 27 May 2008
ORLANDO, FL (UroToday.com) - Dr. Casey Ng and colleagues evaluated whether hydronephrosis in the setting of upper tract TCC was a marker for more aggressive disease and worse outcomes.
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AUA 2008 - Bladder Cancer in Spinal Cord Injury Patients
Tuesday, 27 May 2008
ORLANDO, FL (UroToday.com) - Finally, University of California at Irvine investigators retrospectively evaluated 32/1319 (2.4%) SCI patients who developed bladder cancer that was detected a mean of 34 years (range 16-62) following SCI.
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AUA 2008 - State of the Art Lecture: What are the Most Important Ongoing Clinical Trials in Urologic Oncology Worldwide?
Thursday, 22 May 2008
ORLANDO, FL (UroToday.com) - Dr. E. David Crawford presented information on challenges facing clinical trials from SWOG, ECOG and CALGB.
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AUA 2008 - Strain-Induced Tissue Remodeling in Ex Vivo Bladder Organ Culture: Implications for Regenerative Medicine
Tuesday, 27 May 2008
ORLANDO, FL (UroToday.com) - The moderated poster session covering neurogenic bladder included a broad range of interesting presentations,
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AUA 2008 - Oncologic Follow-Up after Radical Cystectomy: Is there any Benefit?
Friday, 23 May 2008
ORLANDO, FL (UroToday.com) - Tumor recurrence following radical cystectomy (RC) for bladder cancer can be detected in an asymptomatic patient by regular follow-up or in a symptomatic patient by symptom-guided examinations.
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AUA 2008 - Society of Urologic Oncology Meeting - Intravesical Chemotherapy Deserves a Chance
Sunday, 18 May 2008
ORLANDO, FL (UroToday.com) - Professor Witjes pointed out that bladder cancer incidence is much higher in Europe than in the US.
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AUA 2008 - Routine Perioperative Chemotherapy Instillation with Initial Transurethral Resection: A Cross Examination of Economic Benefits
Friday, 23 May 2008
ORLANDO, FL (UroToday.com) - Indisputable level-one evidence has demonstrated decreased recurrence rates of low-grade (LG) bladder tumors when initial bladder tumor resection is followed by chemotherapeutic perioperative instillation (PI).
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AUA 2008 - Protein Expression Patterns of Ezrin are Predictors of Progression in T1G3 Bladder Tumors Treated with BCG
Friday, 23 May 2008
ORLANDO, FL (UroToday.com) -
The ERM proteins (Ezrin, Radixin, and Moesin) and Merlin are closely related members of the band 4.1 superfamily of proteins that, when activated, interact with both membrane proteins and the actin cytoskeleton.
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AUA 2008 - Phase 1 Study of Multi-Dose Administration of Intravesical CG0070 in Patients with Non-Muscle Invasive Bladder Cancer (NMIBC)
Friday, 23 May 2008
ORLANDO, FL (UroToday.com) -
CG0070 is a replication-competent adenovirus modified to replicate preferentially in retinoblastoma pathway-defective cancers and to express granulocyte-macrophage colony-stimulating factor (GM-CSF).
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AUA 2008 - Prognostic Value of Re-TURB of High Risk Non Invasive Bladder Cancer
Friday, 23 May 2008
ORLANDO, FL (UroToday.com) -
The authors evaluated the usefulness of second TURB and whether pathological outcomes of ReTUR have a prognostic impact on recurrence and progression of primitive T1G3 bladder cancer.
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AUA 2008 - A Phase II Study to Evaluate The Efficacy and Tolerability of Intravesical Vicinium™ in Patients with Carcinoma in SITU (CIS) Previously Treated with Bacille Calmette-Guérin (BCG): Preliminary Results
Friday, 23 May 2008
ORLANDO, FL (UroToday.com) -
Vicinium™ is a fusion protein comprised of a humanized scFv, specific for EpCAM (epithelial cell adhesion molecule), and a truncated fragment of Pseudomonas exotoxin A.
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AUA 2008 - The Risk of Persistent Local Disease in Bladder Cancer Patients Found to be Pathologic Stage T0 at Radical Cystectomy
Thursday, 22 May 2008
ORLANDO, FL (UroToday.com) - Pathologic stage T0 (pT0) rates following radical cystectomy (RC) alone range from 10-15%.
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AUA 2008 - Society of Urologic Oncology Meeting - Optimizing BCG Therapy in 2008
Saturday, 17 May 2008
ORLANDO, FL (UroToday.com) - Dr. O’Donnell argued for optimizing BCG therapy in patients failing an initial round of intravesical therapy.
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AUA 2008 - Is Pelvic Lymph Node Dissection Necessary Among Elderly Patients with Bladder Cancer Undergoing a Radical Cystectomy?
Thursday, 22 May 2008
ORLANDO, FL (UroToday.com) - Extension of the pelvic lymph node dissection (PLND) during radical cystectomy (RC) has been proposed to improve patient survival and optimize lymph node count, a potential indicator of surgical quality.
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AUA 2008 - Waiting for Radical Cystectomy – Impact of Wait Times for Cystectomy on Overall Survival
Wednesday, 21 May 2008
ORLANDO, FL (UroToday.com) -
The impact of waiting for radical cystectomy is controversial.
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AUA 2008 - Imaging after Cystectomy for Localized Bladder Cancer – A Survey of the Society of Urologic Oncology
Wednesday, 21 May 2008
ORLANDO, FL (UroToday.com) -
There are no formal guidelines for the surveillance for recurrent transitional cell carcinoma after cystectomy and urinary diversion.
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AUA 2008 - The Role of Urethral Frozen Section at Cystectomy in the Management of Bladder Cancer
Wednesday, 21 May 2008
ORLANDO, FL (UroToday.com) -
While urethral frozen section (FS) is routinely performed in patients with bladder cancer undergoing radical cystectomy, the utility of such FS examination is unclear.
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AUA 2008 - Society of Urologic Oncology Meeting - When is It Time to Treat the Patient and Not the Bladder?
Saturday, 17 May 2008
ORLANDO, FL (UroToday.com) - Dr. Bochner outlined the dilemma of T1G3 bladder cancer.
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AUA 2008 - Prognosis of Pathological T3a and b Bladder Cancer: No Difference between Primarily Invasive and Initially Superficial but Subsequent Progressive Invasive Disease
Wednesday, 21 May 2008
ORLANDO, FL (UroToday.com) -
A Swiss group sought to determine if a prognostic difference exists between primary and initially superficial but subsequently progressive invasive pathological pT3a and b transitional cell carcinoma (TCC) of the bladder.
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AUA 2008 - Society of Urologic Oncology Meeting - Bladder Cancer - Panel with Case Discussion
Saturday, 17 May 2008
ORLANDO, FL (UroToday.com) - Dr. Grossman started by discussing bladder markers.
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AUA 2008 - Long-Term Efficacy Results of EORTC GU Group Study 30911 Comparing Epirubicin, Bacillus Calmette-Guerin (BCG), and BCG Plus Isoniazid in Patients with Intermediate and High Risk Stage Ta T1 Bladder Carcinoma
Wednesday, 21 May 2008
ORLANDO, FL (UroToday.com) -
Intravesical chemotherapy and intravesical BCG both reduce the recurrence rate in patients with stage Ta, T1 bladder cancer, however the benefit of BCG relative to chemotherapy for long-term endpoints, especially in intermediate risk patients, is still controversial.
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AUA 2008 - A Retrospective Analysis of the Effect of Statin Use on the Efficacy of BCG Treatment for TCC of the Bladder
Wednesday, 21 May 2008
ORLANDO, FL (UroToday.com) -
BCG is an effective immunotherapy for carcinoma in situ of the bladder and it reduces recurrences from resected papillary TCC of the bladder.
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AUA 2008 - Late Breaking News: Exciting Developments at the FDA
Tuesday, 27 May 2008
ORLANDO, FL (UroToday.com) - Dr. Andrew von Eschenbach discussed developments at the FDA.
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AUA 2008 - Urine Cytology is of No Added Value in the Primary Evaluation of Patients with Hematuria
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - A group from Amsterdam reported their experience with clinic patients presenting with hematuria are evaluated according to a guideline which was developed by the Dutch Urological Association (DUA) in 1998.
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AUA 2008 - Risk of Bladder Cancer after Childhood Cancer
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - A group of investigators from the UK sought to estimate the risk of bladder cancer (BCa) after childhood cancer, and explore whether cases were originally treated with cyclophosphamide (CPM) or radiotherapy.
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AUA 2008 - Prognostic Significance of HIF-1α Polymorphisms in Transitional Cell Carcinoma of the Bladder
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - Recently, two single nucleotide polymorphisms in the hypoxia-inducible factor-1alpha (HIF-1α) gene, P582S and A588T were shown to cause significantly higher transcriptional activity than the wild type.
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AUA 2008 - Prognostic Significance of Abnormal P-Cadherin Expression in Transitional Cell Carcinoma of the Bladder
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - The roles of E-cadherin and N-cadherin in bladder cancer have been investigated and are linked to the suppression or promotion of invasive potential, respectively.
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AUA 2008 - More Extensive Lymphadenectomy Improves the Prognosis of Patients with Upper Tract Urothelial Carcinoma without Nodal Metastases
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - A large group of international investigators analyzed the prognostic role of the number of lymph nodes removed (LNs) in patients with non-muscle and invasive urothelial carcinoma of the upper urinary tract (UT-UC) managed with radical nephroureterectomy and lymph node dissection (LND).
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AUA 2008 - MRNA Expression Levels and Prognostic Value of 40 Angiogenic Genes in a Large Series of 157 Bladder Tumors
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - During carcinogenesis, angiogenesis is a fundamental process allowing both tumor growth and metastatic spread.
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AUA 2008 - MicroRNA Expression in Bladder Cancer: A Ratiometric Approach Identifies Invasive Potential
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - One third of recurring non-invasive bladder cancer will be invasive.
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AUA 2008 - Metachronous Bladder Tumors in Patients Managed Endoscopically for Primary Upper Tract TCC: Are They Always Predictive of Primary Upper Track Recurrence?
Monday, 19 May 2008
ORLANDO, FL (UroToday.com) - The authors report a retrospective analysis of a 53-patient cohort who underwent systematic urothelial surveillance for at least 24 months following initial endoscopic laser treatment of upper tract TCC.
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AUA 2008 - Experience with Robotic-Assisted Laparoscopic Radical Cystectomy: Peri-Operative and Short-Term Oncologic Outcomes
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - Robot-assisted laparoscopic radical cystectomy (RALRC) while technically challenging has been demonstrated to be very feasible by several investigators.
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AUA 2008 - Robotic-Assisted Laparoscopic Radical Cystectomy: Evaluation of the Learning Curve
Tuesday, 20 May 2008
ORLANDO, FL (UroToday.com) - Chapel Hill investigators (abstract 994) evaluated their learning curve associated with RALRC.
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AUA 2008 - Use of NMP-22, UroVysion and Cytology in Bladder Cancer Surveillance Protocols: Does an Optimal Algorithm Exist? - Poster
Tuesday, 20 May 2008
By Jay B Shah, MD, Karim Kader, MD, Robert S Svatek, MD, H Barton Grossman, MD, Colin PN Dinney, MD, Ruth Katz, MD, Ashish M Kamat, MD
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AUA 2008 - Use of NMP-22, UroVysion and Cytology in Bladder Cancer Surveillance Protocols: Does an Optimal Algorithm Exist? - Slides
Tuesday, 20 May 2008
Jay B Shah, MD, Karim Kader, MD, Robert S Svatek, MD, H Barton Grossman, MD, Colin PN Dinney, MD, Ruth Katz, MD, Ashish M Kamat, MD
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AUA 2008 - Advances in Imaging for Urologic Oncology
Monday, 26 May 2008
ORLANDO, FL (UroToday.com) - Dr. Gill discussed imaging advances for urologic oncology.
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AUA 2008 - FISH vs. Cytology in Post-Cystectomy Tumor Surveillance
Monday, 19 May 2008
ORLANDO, FL (UroToday.com) - This group of authors from San Francisco attempted to push the envelope for the use of FISH in clinical practice.
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AUA 2008 - Decreasing Time to Detection: Use of Fluorescence In Situ Hybridization in Patients with High Risk Superficial Bladder Tumors Undergoing Intravesical Therapy
Monday, 19 May 2008
ORLANDO, FL (UroToday.com) - Has BCG worked?
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AUA 2008 - The Future of Urologic Oncology: Peril and Promise
Monday, 26 May 2008
ORLANDO, FL (UroToday.com) - Dr. Lange presented the Ramon Guiteras lecture.
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AUA 2008 - Results from the San Francisco Firefighters Bladder Cancer Screening Study: Poster
Monday, 19 May 2008
By Kirsten L. Greene, MD, Badrinath Konety, MD, MBA, Hsueh Fu Lu, MD, and Marshall Stoller, MD
University of California, San Francisco
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AUA 2008 - Results from the San Francisco Firefighter Bladder Cancer Screening Study - Slides
Monday, 19 May 2008
By Kirsten L. Greene, MD, Badrinath Konety, MD, MBA, Hsueh Fu Lu, MD, and Marshall Stoller, MD University of California, San Francisco
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AUA 2008 - Adjuvant Chemotherapy for Upper Tract Transitional Cell Carcinoma: Results from the Upper Tract UCC Consortium
Monday, 19 May 2008
ORLANDO, FL (UroToday.com) - Due to its relative low incidence, there is a paucity of literature regarding the use of adjuvant chemotherapy in the management of upper tract urothelial carcinoma (UTUC) and few clinical trials have addressed chemotherapy in this high risk population.
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AUA 2008 - Adjuvant Gemcitabine-Cisplatin Chemotherapy of Invasive Transitional Cell Carcinoma of the Upper Urinary Tract
Sunday, 18 May 2008
ORLANDO, FL (UroToday.com) - A group of Korean researchers evaluated the therapeutic benefit of adjuvant gemcitabine-cisplatin combination chemotherapy (GC) after nephroureterectomy with bladder cuff resection in patients with invasive transitional cell carcinoma (TCC) of the upper urinary tract.
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 AUA 2008 - Evaluation of Urinary Nuclear Matrix Protein 22 Test for Detection of Upper Tract Urothelial Carcinoma - Podcast
Sunday, 18 May 2008
By Dr. Derweesh
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AUA 2008 - Evaluation of Urinary Nuclear Matrix Protein 22 Test for Detection of Upper Tract Urothelial Carcinoma
Sunday, 18 May 2008
ORLANDO, FL (UroToday.com) - The authors assessed the ability of urinary NMP22® BladderChek® Test (from Matritech, a division of Inverness Medical Innovations) to detect upper tract urothelial carcinoma (UT-TCC).
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AUA 2008 - Multi-Institutional Evaluation of the Predictive Value of p53 Immunohistochemical Staining in Patients with pT1-2 No Disease at Radical Cystectomy
Sunday, 18 May 2008
ORLANDO, FL (UroToday.com) - The authors tested whether p53 expression could predict disease recurrence and disease-specific survival after radical cystectomy in patients with pT1-2N0M0 urothelial carcinoma of the bladder (UCB).
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