OBJECTIVE: To assess whether men with a family history of prostate cancer are more likely to fail active surveillance because of recategorization of their tumors on subsequent surveillance biopsies.
METHODS: Men enrolled in an institutional review board-approved active surveillance program were studied, and data on first- and/or second-degree family history of prostate cancer was collected. Analyses were performed to compare the frequency of family history with recategorization (higher grade or volume disease) on surveillance biopsies.
RESULTS: Men with and without family history were recategorized with higher grade disease at a similar frequency (30.9% vs 32.8%). There was no evidence that men with a family history with higher grade disease had more aggressive pathology at the time of radical prostatectomy than men without a family history. Although those with a family history tended to have a shorter time period to recategorization with more positive cores, the difference was not significant.
CONCLUSION: Our results suggest that men with a family history of prostate cancer are not at an increased risk for recategorization on active surveillance. Men with a family history of prostate cancer should not be deterred from considering active surveillance as a treatment option.
Written by:
Selkirk CG, Wang CH, Lapin B, Helfand BT. Are you the author?
Department of Surgery, Division of Urology, NorthShore University HealthSystem, Evanston, IL; Department of Medicine, Division of Medical Genetics, NorthShore University HealthSystem, Evanston, IL; Center for Biomedical and Research Informatics, Research Institute, NorthShore University HealthSystem, Evanston, IL.
Reference: Urology. 2015 Apr;85(4):742-7.
doi: 10.1016/j.urology.2014.10.060
PubMed Abstract
PMID: 25709045