Issue 1s: June 2008

UIJ Volume 1 Issue 1s June 2008

Our Experience in Long Term Neuroblockers in Overactive Bladder


Introduction and Objectives: To estimate possibilities of use of long term neuroblocker - Botulotoxine type A (BoNTA) (BOTOX®) at patients with an Overactive Bladder resistant to anticholinergics therapy.

Solifenacin Improves Urgency in OAB. Results from the SUNRISE and VENUS Studies


Introduction and Objectives

Loss of self esteem and depressive symptoms have been previously reported in women with urinary incontinence.

Assessing the Prevalence and Bother of Lower Urinary Tract Symptoms in the United States, the United Kingdom, and Sweden: EpiLUTS

Introduction and Objectives

No population-based studies evaluating the prevalence of lower urinary tract symptoms (LUTS) in the US using the 2002 ICS definitions have been conducted.

The Impact of LUTS on HRQL, Anxiety, Depression and Treatment Seeking


Introduction and Objectives: Multiple LUTS frequently co-occur, but little is known about the prevalence and patient impact of symptom combinations. A large, multi-country epidemiological study examined the prevalence and impact of LUTS in men and women over 40 in the US, UK, and Sweden.

Treatment of Chronic Cystitis Using Intravesical Silics


Introduction and Objective: Treatment of chronic cystitis remains a significant problem in urology. While treating chronic cystitis we should perform intravesical instillations. Suspension of silics is interesting in this field. Silics–derivative of highly disperse silica–are the preparation with sorbtive properties registered in Ukraine. Silics wasn’t applied in urology earlier. Our study is aimed at the effectiveness and endurance estimation of silics application in patients with chronic cystitis in the acute stage.

Darifenacin Effectively Relieves Symptoms In Patients Regardless of Baseline Severity of Overactive Bladder (OAB)

Introduction and Objectives

Severity of OAB symptoms (Sx) eg incontinence episodes (IEs), urgency, frequency and nocturia varies between pts.

Cost-Utility Analysis of Sacral Nerve Stimulation and Botulinum-A for the Treatment of Urinary Urge Incontinence in Women 65 and Older

Introduction and Objectives

Urgency is the fundamental symptom of overactive bladder syndrome (OAB),1 and is regarded as a driver for many other OAB symptoms.2

Presence of Cardiovascular and Central Nervous System Comorbidities in Patients with Overactive Bladder (OAB) Disorder


Introduction and Objectives: OAB is common in older patients, as are comorbidities that can impact a patient's risk for experiencing AEs. Risk of AEs could also impact a physician’s OAB treatment decisions. Most antimuscarinic agents used in OAB treatment are nonselective and may have adverse cardiovascular (CV) and central nervous system (CNS) effects. Our study objective was to identify the proportion of OAB patients potentially at risk for AEs by assessing important comorbidities (focus on CV and CNS) and concomitant drug use (focus on drugs with known CNS effects). We also sought to assess the impact on OAB treatment decisions, by evaluating the presence of comorbidities and concomitant drug use among treated and untreated OAB patients.

Improvements in Health-Related Quality of Life With Fesoterodine: King’s Health Questionnaire Item Analysis


Introduction and Objectives: Multiple LUTS frequently co-occur, but little is known about the prevalence and patient impact of symptom combinations. A large, multi-country epidemiological study examined the prevalence and impact of LUTS in men and women over 40 in the US, UK, and Sweden.

Refractory Idiopathic Urge Urinary Incontinence and Botulinum A Injection


Introduction and Objectives

The Refractory Urge Incontinence and Botulinum A Toxin Injection (RUBI) randomized clinical trial was designed to compare the effect of 200 U of intra-detrusor Botulinum A toxin (BoNT-A) versus placebo on improvement in urge incontinence symptoms in neurologically normal women with DOI refractory to at least two first-line treatments.

Lipophilicity of 5-Hydroxymethyl Tolterodine, the Active Metabolite of Fesoterodine


Introduction and Objectives: Agents that can easily penetrate the blood-brain barrier (i.e., those with high lipophilicity at physiologic pH) may potentiate central nervous system (CNS) effects. The ability of antimuscarinic agents currently available for the treatment of overactive bladder (OAB) to cross the blood-brain barrier and cause cognitive impairment is of concern, particularly in elderly patients. Fesoterodine (FESO) is a new antimuscarinic agent for the treatment of OAB that is rapidly and extensively hydrolyzed by nonspecific esterases to its only active moiety, 5-hydroxymethyl tolterodine (5-HMT), which is chemically identical to the major active metabolite of tolterodine (Tubaro, A., and C. DeNunzio. [2004]. EAU Update Series 2: 161-169). It has been previously reported that tolterodine, a tertiary amine, has low lipophilicity and low CNS penetration (brain/blood ratio: 0.1 to 0.3 for radioactivity) in mice (Nilvebrant L. Rev Contemp Pharmacother. 2000;11:13-27). A comparison of the chemical structure of tolterodine and 5-HMT suggests that the latter is even less lipophilic owing to hydroxylation. Based on OECD Test Guideline (Nasal, A., et al. [2003]. Curr Med Chem 10: 381-426), the octanol:water distribution coefficient (logD) at pH 7.4 is commonly used to indicate lipophilicity of substances at the pH of blood plasma. The objective of this study was to determine the lipophilicity of 5-HMT compared with antimuscarinic agents currently used for treatment of OAB. 

Antimuscarinics and Heart Rate: Results from a Randomized, Double-Blind, Placebo-Controlled, 3 Way Crossover Study in Subjects Over Age 50

Introduction and Objectives

OAB is common in older pts, as are comorbidities that can impact a pt’s risk for experiencing AEs.

The Role of Muscarinic Receptor Subtype on Detrusor Overactivity induced by Bladder Outlet Obstruction in Rats

Introduction and Objectives

We studied the role of muscarinic receptor subtype on urothelium and detrusor in rats with detrusor overactivity induced by bladder outlet obstruction (BOO).

The Effect of Anti-Muscarinic Agents on Post-Void Residual Urine Volume (PVR) in High Risk Male Patients with Lower Urinary Tract Symptoms (LUTS)



Several studies have demonstrated the efficacy and safety of anti-muscarinics in male patients with lower urinary tract symptoms (LUTS), but few have evaluated their effects on post-void residual urine volumes (PVR) in men at higher risk for developing retention.

Brain Penetration of Trospium Chloride but not of Oxybutynin is Restricted by the Multidrug Resistance Transporter mrd1

ORLANDO, FL ( - Dr. Ira Sharlip, President of the International Society for Sexual Medicine (ISSM) detailed a new definition of premature ejaculation.

Fesoterodine Significantly Improves Treatment Response Rate in Subjects With Overactive Bladder as Early as 2 Weeks: Subpopulation Analyses of a Phase III Trial


Introduction and Objectives: In a previous report of data from this trial, fesoterodine (FESO) was shown to be effective in improving overactive bladder (OAB) symptoms. This subanalysis evaluated the efficacy of FESO as measured by self-reported Treatment Response rates at 2 and 12 weeks in all subjects with OAB and in subpopulations stratified by sex, age, and incontinence status.

Darifenacin Improves Patients’ Perceptions of their Overactive Bladder (OAB) and OAB Symptoms

Introduction and Objectives

The Patient’s Perception of Bladder Condition (PPBC) is a validated measure of a global assessment of treatment benefits (Coyne et al. Eur Urol 2006).

Enhancing Participation of Older Women in Surgical Trials

Introduction and Objective

Recruiting and retaining representative numbers of older participants in trials of therapies that will be prescribed for older persons, particularly surgical therapies, is challenging. Our objective was to describe methodologies used for successful recruitment and retention of older participants in two multisite surgical trials.

Correlation of Fluoroscopic Urodynamic Findings and Lower Urinary Tract Symptoms in Patients with Parkisonism

Introduction and Purpose

Parkinsonism is a neurodegenerative condition of unknown etiology and it accompanies lower urinary tract symptoms.

Adjustable Continence Therapy (ProACT) as a First Line Surgical Treatment of Male Stress Urinary Incontinence (SUI) - Single Center Study

Introduction and Objectives

Male stress urinary incontinence is an unfortunate complication of post radical prostatectomy but may benefit from a number of minimally invasive techniques.