Issue 1s: June 2008

UIJ Volume 1 Issue 1s June 2008

Letter from the Editor - May 2008


Dear Colleagues,

I would like to announce the launch of the UroToday International Journal® (UIJ) (, a new online, peer-reviewed, fast-tracked urology and urologic oncology publication. UIJ focuses specifically on the professional global urology and urologic oncology community. It will elevate the access to relevant urology and oncology science to professionals around the world. UIJ will make the scientific information available to a much wider audience than that reached by other journals, including potential readers who do not have access to a research library that can afford to pay for journal subscriptions. There is no charge to register, submit or publish an article in the UIJ. Additionally there are no charges for color figures. There is no other urology journal offering this unique approach to achieve peer-review publication.

UIJ reaches currently over 55,000 professionals in urology. UIJ will open for general submission of manuscripts on May 31st, 2008 for the July issue.

All manuscripts will be subject to rigorous peer-review. All accepted articles will be given Digital Object Identifier (DOI) numbers so that they can be retrieved and indexed by Pubmed as soon as the pending application from UroToday International Journal has been accepted.

The UroToday International Journal® has an international editorial board headed by myself, Professor at the Institute for Regenerative Medicine at Wake Forest University. The Section/Associate Editors are; Christopher P. Evans, Christian Gratzke and Yasuhiko Igawa. Christopher P. Evans MD, FACS is the Chair of the Department of Urology and Professor & Chairman of Urologic Surgical Oncology University of California, Davis, School of Medicine. Christian Gratzke is an Urologist in the Department of Urology, at the University of Munich in Germany and Yasuhiko Igawa, MD, PhD, is Professor in the Department of Urology at Shinshu University School of Medicine, Japan.Gina B. Carithers is the Publisher of both the UroToday International Journal® and The Managing Editor is Tracy Ireland.

Kind regards,
Karl-Erik Andersson, MD, PhD




The Efficacy and Safety of PSD503 (phenylephrine 20% w/w) for Topical Application in Women with Stress Urinary Incontinence: A Phase II, Multi-Centre, Double-Blind, Placebo-Controlled, Cross-Over Study


Introduction: Stress urinary incontinence (SUI) is the involuntary leakage of urine during periods of increased abdominal pressure (e.g., coughing, running or lifting). It is caused by an incompetent urethral sphincter which may arise as a consequence of damage to the pelvic floor muscles sustained during pregnancy and childbirth. Pharmacological therapy includes the off-label use of sympathomimetic medication (alpha-adrenergic agonists), to enhance urethral tone and alleviate symptoms, however their associated cardiovascular side effects (e.g. hypertension) limits their utility. PSD503 (Plethora Solutions Ltd, London, UK) is a controlled dose topical gel, which contains the alpha-adrenergic agonist phenylephrine (20% w/w). It has been developed as a locally administered treatment for SUI, to increase urethral tone and provide symptomatic relief, in the absence of systemic side effects.

Randomized Trial of a Behavioral Weight Loss Program for Urinary Incontinence in Overweight and Obese Women


Obesity is an established and modifiable risk factor for urinary incontinence (UI) but conclusive evidence for a beneficial effect of weight loss on UI is lacking.

Is the Use of 2-Way Catheter Post-TURP Safe?

Introduction: We present a retrospective study involving 48 patients, who underwent transurethral resection of the prostate (TURP) for bladder outflow obstruction due to prostatic enlargement [4]. The aim of the study was to compare the safety of 2-way catheters post-TURP in relation to the 3-way catheter.

Lower Urinary Tract Dysfunction in Neurological Illness may be Multifactorial: Observations from a Neurorehabilitation Service in a Developing Country


Introduction: Lower urinary tract dysfunction (LUTD) following neurological illness depends upon the level of lesion in the nervous system, causing a characteristic pattern of lower urinary tract symptoms (LUTS). However, a subset of patients may have symptoms that are at variance from the expected pattern.

Weight Loss Improves Urinary Incontinence in Overweight/Obese Women through 18 Months



Obesity is an established risk factor for urinary incontinence (UI).

Neuropathic Faecal Incontinence: Correlation Between Peripheral Axonal Counts and Cortical Activation


Introduction and Objectives: Faecal incontinence is a devastating social and physical handicap affecting 2% of the general population. It is 8 times more common in females than males, largely due to the adverse effects of childbirth on vulnerable pudendal nerves. Our laboratory created 2 rat models simulating faecal incontinence in which the inferior rectal nerve (a terminal branch of the pudendal nerve that supplies the external anal sphincter) is either crushed or compressed. We aimed to determine the effects of these injuries on inferior rectal-nerve axonal counts and cross-sectional areas in our rat models, and to correlate these findings with somatosensory evoked potentials (SSEPs) from the same animals.


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