Volume 1

UIJ Volume 1 2008

Management of Vaginal Synthetic Graft Extrusion Following Surgery for SUI and Prolapse

ABSTRACT

Introduction and Objectives: The objectives of the study were the evaluation of the efficacy and tolerability of propiverine hydrochloride immediate (IR) and extended release (ER) forms comparing placebo in patients with overactive bladder (OAB) and urge urinary incontinence (UUI) in a double-blind, double-dummy, randomized active and placebo-controlled parallel-group phase III/IV trial.

Ultrasound and Magnetic Resonance Imaging of the Anal Sphincter after First Delivery: Relationship to Fecal Incontinence Symptoms

 

Introduction and Objective

To relate symptoms of fecal incontinence (FI) to endoanal ultrasound and magnetic resonance imaging (MRI) findings in a cohort of primiparous women.

Sensitivity of 1-Hour Pad Test to Change in Time of Incontinence Status after Prostatectomy

ABSTRACT

Hypothesis/Aims of Study: Pad testing is a simple, non-invasive, and effective method to quantify the amount of urine loss in patients with urinary incontinence. The short-term tests are easy, quick, and provide immediate information. The pad weight result can serve as an excellent and objective outcome procedure before and after treatment in patients with urinary incontinence. It is important, in this case, for the capacity of a test to be responsive to change in an appropriate way after a change of medical conditions There are few studies in literature that assess the sensitivity of 1-hour pad tests to change incontinence status. The post-prostatectomy incontinence model is ideal for this purpose. In fact, the majority of patients recover urinary control after 1 year from surgery, for a natural recovery of rhabdosphincter function. The aim of this study is to assess the validity and reliability of the 1-hour pad test to detect the changes of post-prostatectomy incontinence and its correlation with the number of episodes of urinary leakage and the results of a validated questionnaire.

Pelvic Support, Pelvic Symptoms and Patient Satisfaction After Colpocleisis

 

Introduction and Objectives

Prostate cancer is the most common onco-urologic pathology among males after age of 50.

Can Bladder Sensations Recorded During Ambulatory Urodynamics be Used for Conditional Nerve Stimulation in Spinal Cord Injury Patients?

Introduction and Objective

Conditional electrical stimulation for neurogenic detrusor overactivity has been studied using involuntary detrusor pressure rises as a trigger to start stimulation.

In Vivo Responses to Urological Biomaterials as Utilized for Urological Reconstruction

ABSTRACT

Introduction and Objectives: Biological tissues are widely used in urological surgeries to treat conditions like pelvic organ prolapse and stress urinary incontinence (SUI). In this study, we examine the in vivo responses of four such agents used clinically in urological reconstruction.


Methods: Four commercially available tissue samples were evaluated from three different companies: Small intestine submucosa (SIS) (Cookbiotech). Tutoplast Fascia lata (FL) (Mentor Corp). Tutoplast Fascia dermis (FD) (Mentor Corp) and Pelvicol (P) (C.R. Bard). The biomaterial was implanted intraperitoneally at the bladder neck of Balb/c mice. Animals were sacrificed at 2, 4, 8, or 12 weeks post-implantation. Bladder and implants were extracted and fixed for histological analysis. Tissue sections were stained for evaluation of fibrous capsule and tissue incorporation. Image analysis using image J software was performed to determine capsule thickness (mm), cell number (mm2), aspect ratio (cell morphology) and angiogenesis.

Results: Tissue extracts were recovered with no noticeable macroscopic inflammatory signs. However, the histological responses to the biomaterials were quite different. Implants from the SIS group were the only group to show a significance decrease in capsule thickness from 2 to 12 weeks of implantation (p=0.01). When examining cell number, we determined that FL and P displayed a decrease in cell number, SIS remained relatively constant and FD increased with time. Interestingly, the aspect ratio of each group was the opposite with FL and SIS having an increasing aspect ratio, while FD and P demonstrated a decreasing ratio with time. At 2 weeks, SIS showed increased number of capillaries with significant angiogenesis.

Conclusions: SIS induced a less pronounced inflammatory response. However, other antigens may be present which elicit inflammatory reactions, thus limiting the implant incorporation and use for long term urological therapies.

Transrectal Linear Array Ultrasonography Complements Urodynamics and Can Reduce Cine' Radiation Exposure

 

Objective

In the investigation of the functions of the bladder and urethra, urodynamics with radiologic cine' need dye and there is an exposure to radiation.

Sacral Neuromodulation in Anal Incontinence and OAB - Evaluation of Preoperative Test Stimulation

Introduction and Objective

To relate symptoms of fecal incontinence (FI) to endoanal ultrasound and magnetic resonance imaging (MRI) findings in a cohort of primiparous women.

TVT-s in Comparison with TVT-o : 12-Month Results

 

In Slovenia tension-free slings (tvt sling) to treat stress urinary incontinence caused by urethral hypermobility and intrinsic sphincter deficiency is used from the year 1998.

Evaluation of Bladder Wall Thickness, Post-Void Residual Volume, Prostate Volume and International Prostate Symptom Score (IPSS) of Patients Undergoing Transrectal Ultrasound

ABSTRACT

Hypothesis / Aims of Study: Pad testing is a simple, non-invasive and effective method to quantify the amount of urine loss in patients with urinary incontinence. The short-term tests are easy, quick, and provide immediate information. The pad weight result can serve as an excellent and objective outcome procedure before and after treatment in patients with urinary incontinence. It is important, in this case the capacity of a test to be responsive to change in appropriate way after change of medical condition. There are few studies in literature that assess the sensitivity of 1- hour pad test to change in time of incontinence status. The post-prostatectomy incontinence model is ideal for this purpose, in fact the majority of patients recover urinary control after 1 year from surgery, for a natural recovery of rhabdosphincter function. The aim of this study is to assess the validity and reliability of 1-hour pad test to detect the changes of post-prostatectomy incontinence, and its correlation with the number of episodes of urinary leakage and the results of a validated questionnaire.

Dose-ranging Pharmacokinetic Study of ANTUROL&#8482 Transdermal Oxybutynin Gel for Overactive Bladder

Objectives

The study was an open-label, randomized, parallel, three-treatment, dose-ranging pharmacokinetic study.

Evaluation of Dynamic MRI Pelvic Floor Measurement Variability in a Multicenter Trial

ABSTRACT

Introduction and Objective: Conditional electrical stimulation for neurogenic detrusor overactivity has been studied using involuntary detrusor pressure rises as a trigger to start stimulation. Detrusor pressure rises were detected by transurethral and transanal catheters for bladder and abdominal pressure registration. The use of these catheters is not suitable in daily life. Some spinal cord injury patients with neurogenic bladder overactivity can sense bladder fullness or involuntary detrusor pressure rises by normal bladder sensations or non-specific bladder sensations, like abdominal fullness or vegetative symptoms. We studied the usefulness of bladder sensations for conditional electrical stimulation in spinal cord injury patients with neurogenic bladder overactivity.

Catheter Care Knowledge: Are Medical Staff Well Trained?

Introduction and Objectives

Biological tissues are widely used in urological surgeries to treat conditions like pelvic organ prolapse and stress urinary incontinence (SUI).

Efficacy and Tolerability of Add-On Trospium Chloride in Patients with an Overactive Bladder and Benign Prostate Syndrome without Obstruction who are Insufficiently Treated with an α-Receptor Blocker

Introduction and Objectives

The present non-interventional study was performed to elucidate efficacy and tolerability of add-on therapy with Spasmex®30 in patients with an overactive bladder (OAB) and benign prostate syndrome (BPS) without obstruction who are insufficiently treated with an α-receptor blocker.

Pharmacokinetic Study of R/S OXY and DEO Enantiomers in ANTUROL Transdermal Oxybutynin Gel for Overactive Bladder

 

Introduction and Objectives

Biological tissues are widely used in urological surgeries to treat conditions like pelvic organ prolapse and stress urinary incontinence (SUI).

The Prevalence of Antibiotic Residence in UTI Comparing Primary and Secondary Care

 

In Slovenia tension-free slings (tvt sling) to treat stress urinary incontinence caused by urethral hypermobility and intrinsic sphincter deficiency is used from the year 1998.

Worldwide Estimates of Current and Future Individuals (≥20 years) With Lower Urinary Tract Symptoms Including Urinary Incontinence and Overactive Bladder

 

Introduction and Objective

Prostatic benign hyperplasia (PBH) is being recognized as a growing health problem worldwide. The incidence of Prostatic Benign Hyperplasia (PBH) has rapidly increased as life expectancy has risen and is now the most common disease in the aging male. Association between PBH and overactive bladder is not uncommon. Patients may present with urgency and urge-incontinence. Quantification of symptoms using the IPSS should be carried out during the initial evaluation. A safe and effective method to evaluate the deleterious effects of bladder outlet obstruction is not yet known. The thickness of the bladder wall measured sonographically has been advocated as a minimally invasive technique and has been widely discussed. In the present study, we analyzed the correlation among bladder wall thickness (BWT), post-void residual volume, prostate volume, IPSS and OAB-V8 symptom questionnaire.

Methods

This prospective observational study included patients who underwent transrectal ultrasound (TRUS) guided prostate biopsy under local anesthesia from January to July 2007. Only patients who had a pre-void bladder volume ranging from 150 to 300 ml in the transrectal ultrasound evaluation were eligible for the study. Several clinical, laboratory and ultrasound parameters were collected including PSA, pre and post-void bladder volume, BWT, prostate volume, IPSS and fluxometry.

Results

Data from 22 consecutive patients were available. The mean age was 66.5 years (+/- 7.02 years). Median PSA was 7.3 ng/mL (ranging from 3.2 to 55.7 ng/mL). Mean prostate volume (TRUS) was 49.32 (+/- 20.2) cm3. IPSS score ranged from 1 to 30 (median = 11.5). Mean BWT was 6.11 (+/- 1.44) mm. Bivariate analysis showed no statistical difference between stratified IPSS and BWT (p=0.55), and no statistical difference between stratified BWT and post-void residual volume (p=0.51). When comparing stratified IPSS (mild versus severe symptoms) and prostate volume, statistical significance was seen (Mann-Whitney, p<0.002). There was no statistical difference when comparing mean peak urinary flow to post-void residual volume (p=0.09).

Conclusions

In the present study, patients with higher IPSS scores had larger prostate volumes (ultrasound evaluation). However, there was not statistical difference between mean BWT and parameters as post-void residual volume, IPSS and OAB-V8 score. The clinical relevance of bladder wall thickness and its association with symptoms of overactive bladder or bladder outlet obstruction should be further studied.

Keywords

Prostate; Bladder obstruction; Ultrasonography; Urinary Incontinence

Application Site Bioequivalence Study of ANTUROL Transdermal Oxybutynin Gel for Overactive Bladder

Objectives

The study was an open-label, randomized, parallel, three-treatment, dose-ranging pharmacokinetic study.

The Adjustable Continence Therapy (ProACT 22) for Male Stress Urinary Incontinence - International Multi-Centre Evaluation

 

Introduction and Objectives

The Adjustable Continence Therapy (ProACT™) was first used as a minimally invasive treatment for male stress urinary incontinence in 2000.

The Effect of Long-Term Treatment of Overactive Bladder on Self Esteem and Depression; Results from a One Year Prospective Study

ABSTRACT

Introduction and Objectives: The loss of self-esteem and depressive symptoms have been previously reported in women with urinary incontinence. Low self-esteem and depression can have a profound effect on quality of life. The incidence of depression in the United Kingdom is estimated between 20 to 25% of women. Self-esteem, defined as the "belief and confidence in one’s own ability and value" is distinct from well being, confidence, and depression. Self-esteem and depression influence health-seeking and coping behaviours and perception of illness and treatment compliance, which are important factors in the successful management of lower urinary tract dysfunction. The objective of this study was to determine whether or not treatment of overactive bladder (OAB) was associated with improvement in self-esteem and depression in women, using validated questionnaires.

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