Upper Tract Urothelial Carcinoma VL

Revolutionizing UTUC Risk Stratification: The Promise of Urinary and Plasma Biomarkers - Helen Hougen

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Sam Chang converses with Helen Hougen about her presentation on predictive biomarkers for upper tract urothelial carcinoma (UTUC) at the SUO, emphasizing their critical role in risk stratification. They delve into the limitations of current diagnostic tools like ureteroscopic biopsies, which often provide imperfect information and pose significant patient burdens. Highlighting the promise of minim...

Route of Administration for UGN-101 and the Impact on Oncological & Safety Outcomes - Jennifer Linehan

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Sam Chang engages with Jennifer Linehan to discuss topical chemotherapy for upper tract urothelial carcinoma, particularly utilizing UGN-101 (Jelmyto). Dr. Linehan shares her invaluable insights and experiences, primarily from the OLYMPUS trial, highlighting the evolution in administration methods for UGN-101, transitioning from retrograde to the more convenient antegrade approach via a nephrostom...

What Every Urologist Should Know About UGN-101 Treatment and its Real-World Implications for Urothelial Cancer - Hristos Kaimakliotis

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Sam Chang engages in a detailed discussion with Hristos Kaimakliotis, who presents findings from a multi-institutional review he authored, focusing on real-world practices with Jelmyto, a treatment for upper tract urothelial cancer. The study explores the efficacy of mitomycin reverse thermal gel, UGN-101, which has shown promise in ablating low-grade upper tract urothelial cancer. The OLYMPUS tri...

Guidelines and Real-World Scenarios in Upper Tract Urothelial Carcinoma Treatment - Kyle Rose

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In a case presentation, Zach Klaassen and Kyle Rose discuss the complexities of treating low-grade upper tract urothelial carcinoma. Dr. Rose presents a case of a 69-year-old male patient with the condition, emphasizing the importance of thorough workup and staging. The discussion covers the challenges of accurate biopsy sampling and the potential for under-staging or over-staging patients. Dr. Ro...

Management of Low-Grade Upper Tract Urothelial Carcinoma: Case-Based Presentation - Rashid Sayyid

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Zachary Klaassen is joined by Rashid Sayyid to present a case-based discussion on the management of low-grade upper tract urothelial carcinoma. They focus on a 68-year-old female patient, detailing her medical history, symptoms, and diagnostic workup, including CT urogram, according to the American Urological Association (AUA) guidelines. They explore various considerations such as standardized re...

Comprehensive Geriatric Assessments in Urologic Cancer Care: Identifying Modifiable Risk Factors for Personalized Treatment - Sarah Psutka

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Sam Chang and Sarah Psutka discuss the importance of personalized prescriptions and rehabilitation in urologic oncology, with an emphasis on frailty evaluation and prehabilitation. Dr. Psutka urges the shift from subjective preoperative risk to objective measures for better treatment outcomes, using Comprehensive Geriatric Assessments (CGA) and anatomic assessments, while highlighting the correlat...

Final Results of a Phase I Trial of WST-11 (TOOKAD Soluble) Vascular-targeted Photodynamic Therapy for Upper Tract Urothelial Carcinoma - Wesley Yip and Jonathan Coleman

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Sam Chang interviews Jonathan Coleman and Wesley Yip. They delve into a Journal of Urology article detailing promising advancements in treating upper tract disease using photodynamic therapy, a non-invasive treatment method developed by Drs. Coleman and Yip. Their study seeks to decrease over-treatment of the disease, which often results in unnecessary kidney removal. Preliminary results show 50%...

Results from the Radical Nephroureterectomy Outcomes (RaNeO) Registry - Clara Cerrato

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In a cross-institutional study investigating the impact of nephroureterectomy on renal function, urologist Clara Cerrato and her international team analyzed data from 576 patients across 17 tertiary centers. They discovered factors such as age, hydronephrosis, and postoperative day one acute kidney injury were independently associated with the estimated glomerular filtration rate (eGFR) variation....

Establishing a Workable Treatment Algorithm for JELMYTO® for Low-Grade Upper Tract Urothelial Carcinoma- Amy Luckenbaugh

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In this discussion, Sam Chang hosts Amy Luckenbaugh, who shares her experience establishing a new treatment program for patients with low-grade upper tract urothelial carcinoma at Vanderbilt, using a novel agent called JELMYTO® (mitomycin). This reverse thermal hydrogel is administered either retrograde or antegrade and has shown encouraging outcomes, with a complete response rate of 58%. Luckenba...

AUA Guidelines for Upper Tract Urothelial Carcinoma: Streamlined Approaches and Novel Opportunities for Treatment - Jean Heather Hoffman-Censits

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Sam Chang speaks with Jeannie Hoffman-Censits about the AUA guidelines on upper tract urothelial carcinoma. They discussed how multidisciplinary panels are important in creating such guidelines and the variability in the treatment of patients with upper tract disease. Dr. Hoffman-Censits mentioned the need for more streamlined and consistent guideline-based approaches to these patients to ensure t...