Upper Tract Urothelial Carcinoma VL

Real-World Experience on the Safety Efficacy of Antegrade Administration of JELMYTO® for UTUC via Percutaneous Nephrostomy Tube - Kyle Rose

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Kyle Rose, SUO Clinical Fellow at Moffitt Cancer Center joins Alicia Morgans in highlighting his AUA presentation on the real-world data on the antegrade administration of reverse thermal mitomycin (JEMLYTO®) for primary chemoablation of upper tract urothelial carcinoma (UTUC). Based on results from the pivotal OLYMPUS trial, JELMYTO® is currently approved for low-grade UTUC. Dr. Rose and colleagu...

A Growing Understanding and Multidisciplinary Approach to Treating Upper Tract Urothelial Carcinoma - Jeannie Hoffman-Censits

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Sam Chang invites Jean Hoffman-Censits to highlight the multidisciplinary work in upper tract urothelial carcinoma (UTUC) with a particular focus on patients that have high-grade UTUC being done at the Greenberg Bladder Cancer Institute at Johns Hopkins University, where Dr Hoffman-Censits is the co-director of the program. Drs. Chang and Hoffman-Censits discuss the current treatment landscape for...

Long-Term Safety and Durability to Non-Surgical Treatment Instillation of UGN-101, Mitomycin-Containing Reverse Thermal Gel for Low-Grade Upper Tract Urothelial Carcinoma, Journal Club - Zachary Klaas...

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In this UroToday Journal Club video presentation, Christopher Wallis and Zachary Klaassen review the Journal of Urology publication "Durability of Response to Primary Chemoablation of Low-Grade Upper Tract Urothelial Carcinoma Using UGN-101, a Mitomycin-Containing Reverse Thermal Gel: OLYMPUS Trial Final Report" led by Drs Surena Matin and Seth Lerner. The goal of this study was to evaluate the lo...

Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy in Patients with High-Grade Upper Tract Urothelial Carcinoma - Wesley Yip

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Wesley Yip and Sam Chang discuss the results of a multicenter trial of neoadjuvant gemcitabine and cisplatin in patients with upper tract urothelial carcinoma (UTUC) presented at the ASCO GU 2022 Cancer Symposium. This phase II multicenter trial of neoadjuvant chemotherapy with gemcitabine and cisplatin in patients with high-risk UTUC prior to extirpative surgery sought to evaluate major outcomes...

Endoscopy in the Setting of Low-Grade Upper Tract Urothelial Carcinoma A Lecture and Discussion - Surena Matin

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Surena Matin joins Sam Chang in a state-of-the-art lecture and discussion on endoscopic management of low-grade upper tract urothelial carcinoma. Dr. Matin highlights several established therapies for the treatment of low-grade upper tract urothelial carcinoma and the two discuss ongoing trials in this disease space. Biographies: Surena F. Matin, MD, Professor, Department of Urology, Division of S...

Molecular Biomarkers in Upper-Tract Urothelial Carcinoma - Janet Kukreja

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Janet Kukreja joins Sam Chang to further highlight her presentation at GU ASCO 2022 focusing on clinical implications of molecular biomarkers in upper tract urothelial carcinoma (UTUC). Currently, the ideal marker does not exist, but we are on our way to more personalized medicine. Drs Chang and Kukreja highlight improved characterization, better identification, risk stratification, and then indiv...

How I Treat Low-Risk Upper Tract Urothelial Carcinoma - Katie Murray

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Sam Chang is joined by Katie Murray to discuss treatment options for low-grade upper-tract disease. As the treatment for this disease has evolved over time, Dr. Murray focuses her presentation on her practice and the nuts and bolts of how she treats upper tract urothelial carcinoma. Biographies: Katie S. Murray, DO, MS, FACS, Assistant Professor of Urologic Oncology, Medical Director-Ellis Fischel...

Radical Nephroureterectomy in Upper Tract Urothelial Cancer - Phillip Pierorazio

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Sam Chang is joined by Phil Pierorazio for a broad discussion on upper tract disease. Dr. Pierorazio provides an overview to help understand the histology of upper tract urothelial cancer and recognize the importance of staging of UTUC disease. Biographies: Philip Pierorazio, MD, Chief of Urology, Penn Presbyterian Hospital, The University of Pennsylvania Philadelphia Sam S. Chang, M.D., M.B.A. Pa...

Antegrade Endoscopic Upper Tract Approaches - Ryan Hsi

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Sam Chang and Ryan Hsi, discuss percutaneous techniques and evaluation for upper tract tumors. Dr. Hsi begins this conversation with a background on antegrade approaches. He discusses the goals of these antegrade approaches to be obtaining tissues and cytologies, while also ablating, resecting, and treating the visible tumor. He also goes on to discuss his approach to using antegrade techniques, w...

Upper Tract Urothelial Carcinoma - Clinical Case Management in High-Risk Disease - Sima Porten

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In this patient case evaluation discussion, Sima Porten joins Sam Chang presenting a case of a 64-year-old man with high-risk urothelial carcinoma. He presented with gross hematuria. His workup initially was started with a cystoscopy that was done by a urologist close to home, which was normal. Biographies: Sima P. Porten, MD, MPH, Assistant Professor, Department of Urology, UCSF Medical Center Sa...
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