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- Although there has been a single retrospective study published of salvage SBRT after brachytherapy, re-irradiation post-brachytherapy (PMID: 36739178) is largely unstudied. Here we present the first prospective trial for salvage SBRT paradigm after brachytherapy, NCT03253744. Biographies: Krishnan R. Patel, MD, Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD Related Content...
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- Jeffrey Tosoian presents a new tool in prostate cancer diagnosis with the development and validation of an 18-gene urine test designed to identify clinically significant prostate cancer published in JAMA Oncology. This research, supported by the Prostate Cancer Foundation (PCF) and the NCI Early Detection Research Network, introduces a novel approach to enhancing the accuracy of prostate cancer de...
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- Andrea Miyahira engages with Jelani Zarif regarding his team’s paper elucidating the metabolic reprogramming of tumor-associated macrophages utilizing the potent glutamine antagonist JHU083. Their dialogue explores the intricate mechanisms underpinning glutamine metabolism within tumor cells and macrophages, unveiling the transformative impact of JHU083 on macrophage functionality. Dr. Zarif artic...
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- Men with localized or locally advanced prostate cancer (LPC/LAPC) are at risk of progression after radiotherapy (RT) or radical prostatectomy (RP). Using real-world data, we evaluated patient characteristics, treatment patterns, and outcomes in LPC/LAPC. Biographies: Stephen J. Freedland, MD, Urologist, Cedars-Sinari, Los Angeles, CA, Staff Physician, Durham VA Medical Center, Durham, NC. Related...
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- Nicholas James and James N'Dow delve into the findings and objectives of the Lancet Prostate Cancer Commission. Professor James outlines the initiative's global scope and multidisciplinary approach to tackling prostate cancer, emphasizing the diverse representation and expertise spanning various regions and specialties. The discussion highlights the comprehensive analysis undertaken over three yea...
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- Nicholas Zorko discusses the promising role of natural killer (NK) cells in prostate cancer, described his team’s study published in Prostate Cancer and Prostatic Diseases. The research reveals that increased NK cell infiltration in prostate tumors correlates with improved patient outcomes, suggesting NK cells as a potential next frontier in cellular therapies for prostate cancer. The study utiliz...
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- Alicia Morgans hosts Daniel Barocas and Bashir Al Hussein Al Awamlh to discuss findings from the CEASAR study published in JAMA, which explores long-term quality of life outcomes for men with localized prostate cancer. Initiated by Dave Penson, this longitudinal study aims to enhance shared decision-making in treatment by providing data on the side effects of various prostate cancer treatments. Fo...
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- Stacy Loeb discusses her study on digital health information trust among Black prostate cancer patients, published in the Journal of Urology. Dr. Loeb's research reveals a stark lack of racial and ethnic diversity in online prostate cancer content, which significantly impacts trust among Black patients. This study, underpinned by analysis of social network use and content representation, involves...
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- Edwin Posadas delves into the complexities and aspirations of the STEEL RTOG 3506 trial, a study initiated as a follow-up to the RTOG 9601 trial's insights into androgen ablation's role in improving outcomes for men undergoing salvage radiation therapy post-biochemical relapse. The STEEL trial, aiming to harness more intensive AR blockade techniques available in modern medicine, embarked on explor...
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- Anqi Wang unveils findings from her study published in Nature Genetics. Dr. Wang's research marks a significant advance in understanding the genetic landscape of prostate cancer, identifying a total of 451 independent risk loci, including 187 novel variants, through an expanded multi-ancestry meta-analysis. This study not only enlarges the scope of known genetic risk factors but also emphasizes th...
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