Prostate Cancer VL

CEASAR Study Reveals Long-Term Quality of Life Outcomes for Localized Prostate Cancer Treatments - Daniel Barocas & Bashir Al Hussein Al Awamlh

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Alicia Morgans hosts Daniel Barocas and Bashir Al Hussein Al Awamlh to discuss findings from the CEASAR study published in JAMA, which explores long-term quality of life outcomes for men with localized prostate cancer. Initiated by Dave Penson, this longitudinal study aims to enhance shared decision-making in treatment by providing data on the side effects of various prostate cancer treatments. Fo...

Representation Matters: Trust in Digital Health Information Among Black Patients with Prostate Cancer - Stacy Loeb

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Stacy Loeb discusses her study on digital health information trust among Black prostate cancer patients, published in the Journal of Urology. Dr. Loeb's research reveals a stark lack of racial and ethnic diversity in online prostate cancer content, which significantly impacts trust among Black patients. This study, underpinned by analysis of social network use and content representation, involves...

The STEEL Trial: Evaluating Enzalutamide Plus ADT with Salvage RT for High-Risk Recurrent Prostate Cancer - Edwin Posadas

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Edwin Posadas delves into the complexities and aspirations of the STEEL RTOG 3506 trial, a study initiated as a follow-up to the RTOG 9601 trial's insights into androgen ablation's role in improving outcomes for men undergoing salvage radiation therapy post-biochemical relapse. The STEEL trial, aiming to harness more intensive AR blockade techniques available in modern medicine, embarked on explor...

New Prostate Cancer Risk Variants Identified in Expanded Multi-Ancestry GWAS Meta-Analysis - Anqi Wang

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Anqi Wang unveils findings from her study published in Nature Genetics. Dr. Wang's research marks a significant advance in understanding the genetic landscape of prostate cancer, identifying a total of 451 independent risk loci, including 187 novel variants, through an expanded multi-ancestry meta-analysis. This study not only enlarges the scope of known genetic risk factors but also emphasizes th...

Plant-Based Diet Associated with Better Quality of Life in Prostate Cancer Survivors - Stacy Loeb

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Alicia Morgans discusses a study with Stacy Loeb, exploring the impact of a plant-based diet on prostate cancer survivors, based on Loeb's paper published in Cancer. Dr. Loeb, motivated by clinical observations and previous findings, delves into a large cohort study from the Health Professionals Follow-Up Study to examine diet's effect on sexual and urinary function among over 3,500 prostate cance...

Novel Computational Approach Identifies NME2-MYC Axis as Biomarker and Therapeutic Target in Enzalutamide-Resistant CRPC - Antonina Mitrofanova

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Antonina Mitrofanova delves into her team's research published in Nature Communications. The study uncovers the NME2 and MYC programs as pivotal markers of enzalutamide resistance in castration-resistant prostate cancer (CRPC). Dr. Mitrofanova's team embarked on this journey following observations that patients with elevated MYC levels showed increased resistance to androgen receptor signal inhibi...

Novel Hormone Therapy and Coordination of Care in High-Risk Biochemically Recurrent Prostate Cancer - Beyond the Abstract

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In this review, Jason Efstathiou and Alicia Morgans discuss challenges associated with Biochemical recurrence (BCR) management and explore the potential benefits and opportunities of multidisciplinary care (MDC) and treatments based on optimizing risk stratification. Biographies: Jason A. Efstathiou, MD, DPhil, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical Schoo...

Unmet Sexual Health Resource Needs and Preferences for Interventions to Address These Needs Among Female Partners of Patients with Prostate Cancer - Natasha Gupta

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Ruchika Talwar hosts Natasha Gupta to explore the overlooked perspective of female partners in prostate cancer care. Dr. Gupta delves into her study on the unmet sexual health needs of female partners of prostate cancer patients, revealing that these partners crave more information and support regarding sexual dysfunction challenges arising from the disease's treatment. Conducting a mixed-methods...

The Impact of Screening Practices for Black Men - Leanne Woods-Burnham

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Samuel Washington engages with Leanne Woods-Burnham to delve into prostate cancer screening for Black men in the U.S., highlighting their discussion at the SUO conference. Dr. Woods-Burnham emphasizes the decline in localized prostate cancer detection following 2012 guideline changes and a concerning rise in metastatic diagnoses, disproportionately affecting Black men. Despite recommendations for...

ARAMON Trial: Darolutamide Monotherapy and Testosterone Levels in Biochemically Recurrent Prostate Cancer - Andrew Laccetti

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Zach Klaassen discusses the ARAMON trial with Andrew Laccetti, which focuses on the impact of enzalutamide and darolutamide on testosterone levels in patients with high-risk nonmetastatic hormone-sensitive prostate cancer. Dr. Laccetti emphasizes the critical need for treatments that not only enhance cancer outcomes but also minimize side effects and improve quality of life for men undergoing long...