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- Phillip Kuo joins Alicia Morgans to discuss recent findings in a VISION sub-study. Dr. Kuo explains how this post-hoc exploratory analysis of the PSMA PET scans that were done for the VISION trial resulted in a better understanding of which patients are likely to respond better to treatment with lutetium-PSMA-617. Biographies: Phillip H. Kuo, MD, Ph.D., Professor of Medical Imaging, Medicine and B...
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- Phillip Koo is joined by Joseph Osborne to provide a nuclear radiologist's perspective on the equity in prostate cancer clinical trials. Dr. Osborne focuses his talk on three different aspects of clinical trial equity for prostate cancer: Progress, Evolution, and Goals. He also details the Rad Health Equity Lab, created at Weill Cornell to improve access to radiology and bring awareness to health...
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- Michael Morris joins Alicia Morgans to discuss the clinical implementation of Pluvicto™ (177Lu-PSMA-617) in a way that ensures equity to all patients, regardless of the many factors that could disrupt access. They discuss equity of distribution to all those patients who need it and the availability of PSMA PET scans. Biographies: Michael Morris, MD, Medical Oncologist Clinical Director, Genitourin...
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- Oliver Sartor joins Phillip Koo to discuss the United State FDA approval of Pluvicto™ (177Lu-PSMA-617) as the first targeted radioligand therapy for the treatment of PSMA positive metastatic castration-resistant prostate cancer (mCRPC). They discuss currently enrolling in clinical trials with Pluvicto in the pre-chemotherapy treated mCRPC patient population. They look further into the future discu...
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- Drs Charles Ryan and Alicia Morgans discuss the approval of Pluvicto TM (lutetium Lu 177 vipivotide tetraxetan) (formerly referred to as 177Lu-PSMA-617). Pluvicto was approved based on the pivotal Phase III VISION trial which evaluated men who had post androgen receptor pathway inhibitor therapy and post docetaxel or docetaxel and cabazitaxel chemotherapy, who were randomized to a protocol-defined...
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- Alicia Morgans converses with Scott Tagawa about patient-reported outcomes in men undergoing PSMA targeted radiopharmaceutical treatments for prostate cancer. The discussion centers on a Department of Defense-funded study that aims to develop a new patient-reported outcome tool specifically for this patient population. Dr. Tagawa elaborates on the instruments commonly used in clinical trials, such...
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- Alicia Morgans with Arun Azad and Declan Murphy about an ongoing clinical trial exploring the use of Lutetium PSMA for treating newly diagnosed metastatic hormone-sensitive prostate cancer. Dr. Azad reveals that the trial aims to assess whether adding Lutetium PSMA to standard chemo-hormonal therapy improves efficacy. The study has garnered significant interest, enrolling over a quarter of its tar...
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- Bennett Chin discusses Lutetium-177 PSMA, an investigational class of targeted, radionuclide agents. The focus of this treatment is on Prostate-Specific Membrane Antigen (PSMA), a molecule overexpressed on higher-grade prostate cancer cells. Lutetium-177 is a radioactive beta emitter that binds to PSMA, delivering highly targeted radiation therapy to prostate cancer cells. This emitter also has mi...
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- PSMA Targeted Therapies in Progressive Metastatic Prostate Cancer Module 1 15 minutes: Radionuclide Targeted Treatment in Progressing Metastatic Prostate Cancer - Presented by Michael Hofman, MBBS (Hons), FRACP, FAANMS, FICIS 20 minutes: Discussion Moderators Phillip Koo, MD, Alicia Morgans, MD, MPH, and Neal Shore, MD, FACS. Biographies: Professor Michael Hofman, MBBS (Hons), FRACP, FAANMS, FICIS...
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- PSMA Targeted Therapies in Progressive Metastatic Prostate Cancer Module 2 12 minutes: PSMA-PET Diagnostic Imaging in Prostate Cancer - Presented by Thomas Hope, MD Module 3 16 minutes: PSMA as a Therapeutic Target in Progressing Prostate Cancer - Presented by Johannes Czernin, MD 22 minutes: Discussion moderators Phillip Koo, MD, Alicia Morgans, MD, MPH, and Neal Shore, MD, FACS. Biographies: Joh...
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