177Lu-PSMA-617 Patient Administration in the Tulane Cancer Center Radioligand Clinic - Kendra Harris

August 23, 2021

177Lu-PSMA-617 is a beta emitter radioligand therapy in advanced prostate cancer that delivers radiation directly to cancer cells and is one of the recent advances in the treatment of advanced prostate cancer. This video observes Dr. Kendra Harris, a radiation oncologist administering a 177Lu-PSMA-617 dose to Mr. Monroe, a prostate cancer patient on his recent visit to the Tulane Cancer Center. 

The Tulane Cancer Center, New Orleans, Louisiana is leading the expanded access program for the administering of 177Lu-PSMA-617 for patients with metastatic castration-resistant prostate cancer (mCRPC).


Kendra Harris, MD MSc, Chair Radiation Oncology, Associate Professor, Tulane Cancer Center, Tulane University School of Medicine

Read the Full Video Transcript

Kendra Harris: Now, if you would do us a favor, we need to do a timeout. So if you would say your name and date of birth. So first, I'm going to carefully check that I like your IV. All of these are filled with saltwater.

Mr. Monroe: Okay.

Kendra Harris: Typically, I'll check with one syringeful, and then after the dose is administered-

Mr. Monroe: You'll flush it.

Kendra Harris: You got it.

Mr. Monroe: Yep.

Kendra Harris: You got it.

Mr. Monroe: I know the drill.

Kendra Harris: An expert, even though it's your first time, huh?

Mr. Monroe: [inaudible 00:00:31] they did that a lot.

Kendra Harris: Oh, did they? Gotcha.

Mr. Monroe: Yeah. They flushed it a lot.

Kendra Harris: All right. So I'm just going to check that I like your IV.

Mr. Monroe: Is that Budweiser or Coors Light?"

Tony: What would you like?

Kendra Harris: I don't know, it looks like vodka. Just a little bit of saltwater. It's got a nice flow...

Mr. Monroe: I taste it.

Kendra Harris: All right. So the IV is great.

Mr. Monroe: Okay.

Kendra Harris: Tony, you want to pop over there and grab it? Thank you, sir.

Kendra Harris: It's a bit anti-climatic, I got to tell ya. But this is your medicine. I'm going to go ahead and attach it to your IV.

Mr. Monroe: Thank you.

Kendra Harris: Then I can see the amount there.

Mr. Monroe: Okay.

Kendra Harris: I, again, release your IV. Tony, are you ready with the time?

Mr. Monroe: 
It's not full, it's about half full.

Tony: Yes ma'am.

Kendra Harris: You got it. Yep. Starting now. So I just push it in slowly. I try to do it over about a minute.

Mr. Monroe: You know that question you and I talked about the other day about my insurance? If it was going to...

Kendra Harris: Oh yeah.

Mr. Monroe: They are.

Kendra Harris: Oh, fantastic.

Mr. Monroe: Yeah. Checked on that Friday.

Kendra Harris: That's great. We sure appreciate you being flexible today.

Mr. Monroe: Well, I told her I can be here in two and a half to three hours.

Kendra Harris: And indeed here you are.

Mr. Monroe: Yep.

Kendra Harris: Yep.

Mr. Monroe: So at nighttime, they'll see me glowing around the house in the dark.

Kendra Harris: Well, if you do, it's not my fault. No, we'll be giving you a very specific set of instructions related to precautions.

Mr. Monroe: She went over that with me already.

Kendra Harris: Yeah. And certainly, if you have any questions at all, I want you to be in touch with me about it.

Mr. Monroe: 

Kendra Harris: All right.

Mr. Monroe: Looks like we're done.

Kendra Harris: Hold on. I want to make sure that we get the last little bit, there we go.

Mr. Monroe: Did you get your clinical trials for your children?

Kendra Harris: I did.

Mr. Monroe: Thank God.

Kendra Harris: I did. I know.

Mr. Monroe: Glad for them.

Kendra Harris: Thank you. Yep, my kiddos will be getting the Moderna vaccine.

Mr. Monroe: I did the Pfizer in December and January.

Kendra Harris: That's wonderful. That's what I did as well. So I put the empty syringe back in...

Mr. Monroe: In the lead container?

Kendra Harris: In the lead igloo. And then I go ahead and do the flush.

Tony: See?

Mr. Monroe: There it is.

Speaker 4: Can I see that Tony? The screen?

Tony: Oh, sure.

Speaker 4: Thank you.

Kendra Harris: Yeah, the main thing to remember is, any of the radioactive lutetium that doesn't stick to your cancer, you're going to pee it out.

Mr. Monroe: Okay.

Kendra Harris: Predominantly over the next day or two. So those precautions are especially important.

Mr. Monroe: I understand. Charlotte went over that with me a little earlier.

Kendra Harris: Yeah.

Mr. Monroe: Any diet and drinks, or any limitations to anything?

Kendra Harris: No. I just think it would be wise to stay well hydrated.

Mr. Monroe: Yeah. So if I want to go home tomorrow and cut the grass, I can do it.

Kendra Harris: Yes. Take a big old jug of water with you.

Mr. Monroe: All right.

Kendra Harris: We've got a heat index of 120.

Mr. Monroe: Let me tell you, at home this morning y'all, it was 66 degrees.

Kendra Harris: Was it really?

Mr. Monroe: Yes.

Kendra Harris: That sounds awesome.

Mr. Monroe: 
It was awesome.

Kendra Harris: Last one. So basically once I finish this syringe, we'll go ahead and give you 15 minutes, we'll do a set of vitals, and then I'll take your IV out, and then we'll be done.

Mr. Monroe: Thanks.

Kendra Harris: Yeah. That's it. All done.

Mr. Monroe: Very good.

Kendra Harris: I'm going to have you lift your arm for me. Thank you, sir.

Tony: And let me give you a wand at the door [inaudible 00:04:57]

Kendra Harris: Yes. Before I am set free in the department he-

Mr. Monroe: [inaudible 00:05:05] 

Kendra Harris: Yeah.

Tony: So we're just going to take measurements to verify that she's clean.

Kendra Harris: We have to move back from the door. Are we good?.

Tony: Back of feet.

Kendra Harris: Yep.

Tony: Okay. Good.

Kendra Harris: How are you feeling?

Mr. Monroe:  Good.

Kendra Harris: All right, I'm just going to do a quick set of vitals, then I'll pull your IV, and then you'll be out. Thank you, sir. Thank you. 143 over 96. 89.

Mr. Monroe: That's very high.

Kendra Harris: Yeah. So the special things he gets to do; includes things like sitting while urinating, after you have emptied your bladder into the toilet you would flush twice. You would also clean your clothes separate from those of your lovely wife. Because there is sometimes a little bit of dribbling. And then certainly, just awareness in terms of, if there were any accidents, that would be a different category of the event. And you've got my cell phone. So you can always reach out if you've got questions about it.

Mr. Monroe: Okay.

Kendra Harris: So I think we can pull your IV.

Mr. Monroe: Sounds good.

Kendra Harris: I think everybody's reeling from Delta. I don't know what they are going to do. If they're going to have the stadium open full capacity.

Mr. Monroe: Absolutely. Exhibition game before long and high school games around the corner. So all that's been interesting to see what's going to happen.

Phillip Koo: My fantasy football draft is in four weeks, three weeks.

Kendra Harris: Yeah.

Mr. Monroe: Thank you.

Kendra Harris: Safe travels.

Mr. Monroe: All right. See you later.

Kendra Harris: Nice to see you.

Mr. Monroe: 
Okay, I got to follow you.

Phillip Koo: Thank you very much.

Mr. Monroe: Thank you all.

Kendra Harris: Thank you.

Phillip Koo: Nice to meet you.