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- Alicia Morgans is joined by Seth Lerner and discuss his State-of-the-Art Lecture on Bacillus Calmette–Guérin (BCG) unresponsive disease in non-muscle-invasive bladder cancer. They discuss the FDA’s guidance in terms of clinical trial design in the BCG-unresponsive disease space and recap where the treatment landscape is now and what is on the horizon as far as molecular subtypes and predictive bio...
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- Ashish Kamat is joined by Patrick Lewicki to discuss the recent publication on the underutilization of Blue Light Cystoscopy (BLC) in the United States. Studying the use of BLC in the Premier Healthcare Database, the findings demonstrate a low level of BLC use despite guideline recommendations and evidence demonstrating the benefit for its use in the management of non-muscle invasive bladder cance...
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- Richard Matulewicz joins Ashish Kamat presenting findings on the association of smoking status on recurrence of non-muscle invasive bladder cancer (NMIBC) in a contemporary cohort of patients with predominantly high-risk, recurrent NMIBC managed with photodynamic enhanced cystoscopy. A retrospective study was conducted in a multi-institutional registry. Smoking has a strong causal association with...
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- John Sfakianos and Amir Horowitz join Ashish Kamat discussing a novel immune checkpoint axis in non-muscle-invasive bladder cancer, specifically looking at the HLA-E and NKG2A axis in non-muscle invasive bladder cancer, as it relates to Bacillus Calmette-Guerin (BCG) and BCG resistance. Biographies: Amir Horowitz, Ph.D., is an Assistant Professor of Oncological Sciences and a member of the Precisi...
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- Joining Ashish Kamat from the Moffit Cancer Center in Tampa, Florida is Roger Li to dive into all things BCG unresponsive bladder cancer. Dr. Li shares what is known about BCG unresponsive disease, some of the conundrums that clinicians and the FDA are challenged by when evaluating and designing clinical trials in this area, and answers a series of questions from Dr. Kamat covering many topics in...
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- Eugene Pietzak, MD joins Ashish Kamat, MD MBBS, to discuss an investigator-initiated trial, "Combination BCG and Intravesical Gemcitabine (CBIG) in Patients with BCG Relapsing Non-Muscle Invasive Bladder Cancer" (NCT04179162) that is currently recruiting. Dr. Pietzak explains the rationale for the trial design and the background on the questions this trial seeks to understand, in the combination o...
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- Yair Lotan, MD, and Daniel Parker, MD join Ashish Kamat, MD, MBBS in a discussion on the efficacy and utilization of Blue Light Cystoscopy (BLC) Cysview® (hexaminolevulinate HCl). Dr. Lotanoffers his perspective on the use of blue light cystoscopy in bladder cancer detection in the hospital and Dr. Parker offers his perspective on the use in the office. Studies have shown that BLC improves the det...
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- Siamak Daneshmand and Marek Babjuk join Ashish Kamat in this conversation on improving tumor detection through improved visibility and reducing recurrence rates of bladder cancer. Siamak Daneshmand offers his perspective on the use of Blue Light Cystoscopy (BLC®) with Cysview® for improving detection and reduced recurrence of bladder cancer. Marek Babjuk presents his perspective on the use of phot...
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- Subtypes in non-muscle-invasive bladder cancer are not well-defined, whereas the molecular landscape of muscle-invasive bladder cancer is relatively well-established. During the optimizing personalized management of non-muscle-invasive bladder cancer session at the American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU), Eugene Pietzak, MD, discussed the molecular landscape...
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- In this conversation with Ashish Kamat, Sita Vermeulen details a perspective recently published in Nature Reviews Urology on trained immunity as a molecular mechanism for Bacillus Calmette-Guerin or BCG immunotherapy in bladder cancer. BCG is the gold standard adjuvant therapy for high-risk nonmuscle-invasive bladder cancer (NMIBC). One of the aspects of innate immunity that has not been a topic o...
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