nmCRPC VL

ARAMIS Trial in Prostate Cancer: Impact of Darolutamide on Pain and Quality of Life - Karim Fizazi

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Karim Fizazi and Alicia Morgans discuss a follow-up on the quality of life parameters evaluated in the ARAMIS trial. Darolutamide was also associated with benefits with regard to all secondary end points, including overall survival, time to pain progression, time to cytotoxic chemotherapy, and time to a symptomatic skeletal-related event. The incidence of adverse events that occurred or worsened d...

Darolutamide Demonstrates Efficacy and Safety in Men with nmCRPC - Neeraj Agarwal

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Petros Grivas discussed Neeraj Agarwal's insights about the latest prostate cancer study results that will impact patient care as presented at ASCO GU 2019. The ARAMIS trial evaluated the efficacy of darolutamide for delaying metastasis and death in men with nonmetastatic, castration-resistant prostate cancer. Darolutamide is a structurally unique androgen-receptor antagonist that is under develop...

ARAMIS - Efficacy and Safety of Darolutamide in nmCRPC - Karim Fizazi

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Karim Fizazi discusses the efficacy and safety of darolutamide with Alicia Morgans. The ARAMIS trial evaluated the efficacy of darolutamide for delaying metastasis and death in men with nonmetastatic, castration-resistant prostate cancer (nmCRPC). Darolutamide is a structurally unique androgen-receptor antagonist that is under development for the treatment of prostate cancer. In total, 1509 patien...

Delaying Disease Progression in Early Nonmetastatic CRPC Treatment - Fred Saad

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In this interview, Fred Saad reviews current and new agents showing benefit in the nonmetastatic castrate-resistant prostate cancer (nmCRPC) space and where the treatment paradigm stands in 2019 since data release in 2018. In addition, Fred makes the case for earlier treatment in nmCRPC patients and how targeting the androgen receptor is extremely effective which leads to better survival rates and...

Abiraterone Acetate for nmCRPC, The Forgotten Dance Partner? - Zach Klaassen and Chris Wallis

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Zach Klaassen and Chris Wallis discuss a jointly published paper that was published in Jama Oncology, November, titled, “Abiraterone Acetate for Nonmetastatic Castration-Resistant Prostate Cancer, The Forgotten Dance Partner?” They reference recent trials in this space and discuss cost and other variables to consider when making a therapeutic decision. Biographies: Zachary Klaassen, MD, MSc, Urolo...

IMAAGEN Trial: A Look into the Non-Metastatic Prostate Cancer Space - Charles Ryan

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(Length of Discussion: 20 min) Alicia Morgans and Charles Ryan have a dialogue on the study design, results and conclusions from the IMAAGEN trial in the non-metastatic prostate cancer space. The IMAAGEN trial evaluated the use of abiraterone acetate (1,000 mg) plus prednisone (5 mg) in patients with high risk, nonmetastatic, castration resistant prostate cancer. Biographies: Charles J. Ryan, MD A...

Comparison Between Surgery and Radiotherapy in the Treatment of Non-Metastatic Prostate Cancer- Christopher Wallis

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(Length of Presentation: 8 minutes) Christopher Wallis presents observational data from a large, population-based matched cohort demonstrating an association between treatment with radiotherapy vs radical prostatectomy and non-prostate cancer mortality. This controversial topic in urologic oncology is a usual subject of interest with respect to comparative effectiveness studies. In observational s...

Phase III ARAMIS Trial Darolutamide in Patients with Non-metastatic Castration-resistant Prostate Cancer Meets Primary Endpoint - Tom Keane

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(Length of video: 5 min) Tom Keane, MBBCh, FRCSI, FACS provides highlights of the recent press release of ARAMIS, a phase III trial of darolutamide in patients with non-metastatic castrate-resistant prostate cancer. Darolutamide significantly extended metastasis-free survival compared to placebo, meeting its primary endpoint. The safety profile and tolerability of darolutamide observed in the ARAM...

Combination Therapies and Quality of Life Data in Prostate Cancer - Fred Saad

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Charles Ryan and Fred Saad discuss the data results in patients with mCRPC from a combined therapeutic approach with abiraterone and apalutamide. They discuss the rationale and theory behind these results. They move to discuss the quality of life analysis for patients with CRPC. A review of the SPARTAN trial and the optimistic results from his work. Biographies: Fred Saad MD FRCS is a full-time pr...

nmCRPC Patient Population - Discussion with Charles Ryan and Alicia Morgans

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Charles Ryan and Alicia Morgans discuss the nmCRPC patient population and what is the meaning of the term "nonmetastatic" prostate cancer. They highlight the relevance of meaningful dialogue that should be had with patients to assure the right treatment choice is made. Biographies: Charles J. Ryan, MD Alicia Morgans, MD, MPH