nmCRPC VL

Depression, Bone Health and Exercise in Prostate Cancer - Fred Saad, Tomasz Beer & Charles Ryan

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Alicia Morgans is joined by Drs Fred Saad, Charles Ryan, and Tomasz Beer at the 2022 Advanced Prostate Cancer Consensus Conference (APCCC) in Lugano, Switzerland, to discuss holistic treatment of men with prostate cancer who are being treated with ADT. Dr. Ryan discusses the lack of data on the treatment of depression in men on hormone therapy. Dr. Saad discusses the need to be aware of the patien...

Mental Health and Impact on Patients with GU Malignancies - Zachary Klaassen

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Zach Klaassen joins Alicia Morgans in discussing an underestimated topic of mental health and its effects on patients with genitourinary cancers. Drs. Klaassen and Morgans discuss hypothesis-generating population-level data in this landscape and talk through the importance of supporting these patients and using what Dr. Klaassen refers to as clinical intuition and asking follow-up questions when s...

Combination Therapy Associated with Significantly Higher Rates of MFS Compared with ADT Alone Among Men with High-Risk Nonmetastatic Prostate Cancer: STAMPEDE Platform Protocol, Journal Club- Christop...

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Christopher Wallis and Zachary Klaassen discuss the publication in the Lancet analyzing new data from the STAMPEDE trial of two randomized controlled phase 3 trials done in a multiarm, multistage platform protocol to assess the efficacy of adding abiraterone and prednisolone alone or with enzalutamide to androgen-deprivation therapy (ADT) in men with high-risk non-metastatic prostate cancer. Biogr...

The Impact of Imaging and Therapeutics Advances in Nonmetastatic Castration-Resistant Prostate Cancer - David Penson

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David Penson joins Alicia Morgans to discuss the rapidly changing landscape in prostate cancer, focusing on how imaging and therapeutic advances have disrupted the landscape in the nonmetastatic castration-resistant prostate cancer (CRPC) setting. Dr. Penson highlights advancements in PSMA scanning and how it impacts potential study inclusion criteria. Drs. Morgans and Penson also discuss PSMA PET...

Time Course Profile of Adverse Events With Darolutamide in the ARAMIS Trial – Christian Gratzke

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Alicia Morgans is joined by Christian Gratzke to discuss data presented at the European Society of Medical Oncology (ESMO) 2021 annual meeting around the time course profile of adverse events with darolutamide in the ARAMIS phase 3 trial. The ARAMIS trial was a phase three multicenter randomized control trial, comparing darolutamide versus placebo in combination with ADT in non-metastatic castrati...

Cognitive Assessment in Men with Metastatic Castrate-Resistant Prostate Cancer (mCRPC) Randomly Receiving Darolutamide or Enzalutamide in the ODENZA Trial - Karim Fizazi

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Karim Fizazi joins Alicia Morgans in discussing the 2021 European Society for Medical Oncology (ESMO) presentation of the results from the ODENZA trial comparing darolutamide and enzalutamide, with a focus on cognitive assessment. ODENZA is a French prospective, randomized, open-label, multicenter, cross-over phase II trial of preference between darolutamide and enzalutamide in men with asymptomat...

Delayed Deterioration in Patient Quality of Life, the Impact of Darolutamide on Local Symptoms in the ARAMIS Trial – Neal Shore

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Alicia Morgans is joined by Neal Shore to discuss his presentation from the 2021 American Urologic Association (AUA) annual meeting on the relationship between PSA response and urinary and bowel adverse events (AEs), time to deterioration in the quality of life, and prostate cancer related invasive procedures in the ARAMIS trial. The authors examined the proportion of darolutamide patients achievi...

STAMPEDE Analysis of Abiraterone With or Without Enzalutamide Added to Androgen Deprivation Therapy Compared to ADT Alone In High-Risk Non-Metastatic Prostate Cancer Patients– Gerhardt Attard

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Gerhardt Attard joins Alicia Morgans to discuss a combined analysis from two comparisons in the STAMPEDE platform. Dr. Gerhardt Attard presented a combined analysis from the STAMPEDE platform assessing the role of abiraterone acetate plus prednisolone (AAP) with or without enzalutamide (ENZ) added to androgen deprivation therapy (ADT) compared to ADT alone for men with high-risk non-metastatic (M0...

Overall Survival Data from the Global, Phase 3 ARAMIS Trial in Men with Non Metastatic Castration-Resistant Prostate Cancer (nmCRPC) - Karim Fizazi

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Importance of early intervention in nmCRPC—A discussion with Karim Fizazi, MD, PhD. Darolutamide, an androgen receptor inhibitor, was developed to improve the safety profile of apalutamide and enzalutamide. It has a distinct structure that offers low penetration of the blood-brain barrier as well as other characteristics with the potential for fewer and less toxic adverse events (AEs). The primary...

Predictors of Survival, Healthcare Resource Utilization, and Healthcare Costs in Veterans with Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC) - Stephen Freedland

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In this discussion, Stephen Freedland, MD, joins Alicia Morgans, MD, MPH, to discuss a health economics study that was recently published titled, Predictors of survival, healthcare resource utilization, and healthcare costs in veterans with non-metastatic castration-resistant prostate cancer. The objective of this study was to evaluate the association of prostate-specific antigen doubling time (PS...
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