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- Mary-Ellen Taplin, Professor of Medicine Harvard Medical School and a GU Medical Oncologist at the Dana-Farber Cancer Institute, joins Alicia Morgans to speak about the ProGen study. A randomized controlled trial that aims to evaluate the impact of pre-test video education and post-test genetic counseling as compared to in-person pre-test genetic counseling in males with advanced prostate cancer....
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- Hala Borno joins Alicia Morgans and discusses a recent viewpoint article in JAMA Oncology titled “The Ethics of Delivering Precision Medicine—Pretest Counseling and Somatic Genomic Testing.” In the new era of precision medicine in cancer treatment, many clinicians use patient tumor genomic (somatic) data as part of routine clinical practice. Dr. Borno shares insights into Pretest Counseling in an...
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- Together with Alicia Morgans, Maria Carlo delves into the topic of germline testing for patients with genitourinary malignancies. In a more non-traditional approach to investigating the effects of DNA repair defects on prostate and bladder cancer, Carlo factors in not only oncological outcomes, but also psychological outcomes of her clinical trials. Biographies: Maria Carlo, MD, Medical Oncologist...
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- Elena Castro joins Dr. Alicia Morgans at the 2019 Prostate Cancer Foundation Retreat (PCF 2019) to discuss PROREPAIR-B. This was an academic prospective observational study evaluating the prevalence and impact of germline mutations in BRCA1, BRCA2, ATM and PALB2 on metastatic castration-resistance prostate cancer (mCRPC) outcomes. Biographies: Elena Castro, MD, Prostate Cancer and Genitourinary Tu...
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- In this conversation, Alicia Morgans and Rosalind Eeles discuss how patients should be selected for genetic counseling and testing. This discussion highlights several important questions including: What is the spectrum of genetic predisposition that we currently know? How should we use this? Who should be tested? Are there international discrepancies in the guidelines? How do we manage men who are...
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- During the Molecular Biomarkers and Novel Imaging in Advanced Prostate Cancer session at the Advanced Prostate Cancer Consensus Conference (APCCC 2019), Dr. Rosalind Eeles discussed how patients should be selected for genetic counseling and testing. She highlights several key points for clinicians to consider when thinking through how we should think about which men should be tested for genetic ab...
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- Eli Van Allen shares details on The Metastatic Prostate Cancer Project, a project part of a larger nationwide genomic research project called "Count Me In" for men with advanced or metastatic prostate cancer. The Metastatic Prostate Cancer Project takes a new approach to cancer research in which researchers partner directly with men with metastatic and/or advanced prostate cancer, who share their...
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- In the era that genomics and genetics are really making an impact to clinical practice and with the recent positive results of the PROfound study, Alicia Morgans and Colin Pritchard have a discussion thinking about this data, how do we implement it, and how do we work with our pathologists to make things happen? Colin highlights this game-changing genomic markers data, particularly for homologous...
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- Jacob Berchuck, MD and Mary-Ellen Taplin, MD join Alicia Morgans in discussing areas of genetic risk in high-risk localized prostate cancer. They discuss the complexity of screening patients and incorporating the identifying of patients for genetic risk into clinical workflow. Jacob shares details on a collaboration with Mark Pomerantz at Dana-Farber and Phil Kantoff at Memorial Sloan Kettering, a...
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- Sarah Abou Alaiwi, MD discusses her recently presented bench to bedside research with Monty Pal, MD. She explains that PBRM1 is frequently mutated around 40% on Renal Cell Carcinoma. It is part of this Mammalian SWI/SNF complex, which is really what drove interest in this complex. This complex is really huge. It has 29 subunits. It's frequently mutated in around 20% of all human cancers. There is...
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