Molecular Diagnostics VL

Imaging-Based Prostate Cancer Screening Among BRCA Mutation Carriers - A UroToday Journal Club

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Male-carriers of BRCA1/2 gene mutations have an increased risk of prostate cancer (PCa) with a more aggressive phenotype. Current screening-guidelines suggest the use of prostate-specific antigen (PSA) only among BRCA2 carriers. Female carriers have extensive guidelines that include imaging. The study objective was to test the prevalence of prostate cancer among BRCA carriers and examine screening...

Operationalizing Genomic Testing for Clinical Practice In Prostate Cancer - Jason Hafron

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Jason Hafron, MD, joins Alicia Morgans, MD, MPH in a conversation on operationalizing genomic testing in clinical practice, towards supporting the use of PARP inhibitors in the appropriate patients. Dr. Hafron emphasizes the key to this success begins with the implementation of clinical pathways. With streamlined accurate clinical pathways, we can speed up the process and provide care to the patie...

BRCA1/2 and Beyond - Molecular Diagnostic Testing and Treatments with PARP Inhibitors for mCRPC - Joaquin Mateo

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In May 2020, the United States Food and Drug Administration approved olaparib for adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC), who have progressed following prior treatment with enzalutamide or abiraterone. Efficacy was investigated in the PROfound study, a pr...

Pembrolizumab in mCRPC Patients with Microsatellite Instability High (MSI-H) Detected by Circulating Tumor DNA - Pedro Barata

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Joining Alicia Morgans, MD, MPH, is Pedro Barata, MD, MSc, a co-author of the paper titled, "Clinical activity of pembrolizumab in metastatic prostate cancer with microsatellite instability-high (MSI-H) detected by circulating tumor DNA." Dr. Barata provides the background behind the multi-institutional case series explaining that the use of liquid biopsy in identifying metastatic prostate cancer...

The Role of FoundationOne® Liquid CDx in mCRPC - Oliver Sartor

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Oliver Sartor, MD joins Alicia Morgans, MD, MPH to discuss the US Federal Drug Administration (FDA) recent approval of the FoundationOne® Liquid CDx biopsy test that informs precision medicine in mCRPC. This is a companion diagnostic that serves as a predictive biomarker to identify patients who may benefit from targeted therapies including rucaparib, a poly (ADP-ribose) polymerase (PARP) inhibito...

Intersection of Germline and Somatic Testing - Colin Pritchard and Heather Cheng

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Colin Pritchard, MD, PhD, Heather Cheng, MD, PhD, and Petros Grivas, MD, PhD, join Alicia Morgans, MD, MPH, to discuss the increasing role of molecular diagnostics and testing in genitourinary cancers. Dr. Pritchard begins by highlighting the advantages of the University of Washington and Seattle Cancer Care Alliance’s GU molecular tumor board. By providing clinicians the opportunity to discuss tu...

The Delivering of Genetic Counseling, Processes and Outcomes, The ProGen Study - Mary-Ellen Taplin

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Mary-Ellen Taplin, Professor of Medicine Harvard Medical School and a GU Medical Oncologist at the Dana-Farber Cancer Institute, joins Alicia Morgans to discuss the ProGen study. A randomized controlled trial that aims to evaluate the impact of pre-test video education and post-test genetic counseling as compared to in-person pre-test genetic counseling in males with advanced prostate cancer. This...

The Ethics of Delivering Precision Medicine — Hala Borno

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Hala Borno joins Alicia Morgans and discusses a recent viewpoint article in JAMA Oncology titled “The Ethics of Delivering Precision Medicine—Pretest Counseling and Somatic Genomic Testing.” In the new era of precision medicine in cancer treatment, many clinicians use patient tumor genomic (somatic) data as part of routine clinical practice. Dr. Borno shares insights into Pretest Counseling in an...

Germline Testing for Patients with Genitourinary Malignancies - Maria Carlo

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Together with Alicia Morgans, Maria Carlo delves into the topic of germline testing for patients with genitourinary malignancies. In a more non-traditional approach to investigating the effects of DNA repair defects on prostate and bladder cancer, Carlo factors in not only oncological outcomes, but also psychological outcomes of her clinical trials. Biographies: Maria Carlo, MD, Medical Oncologist...

The Prevalence and Impact of Germline Mutations, PROREPAIR-B Trial - Elena Castro

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Elena Castro, MD joins Alicia Morgans, MD, MPH at the 2019 Prostate Cancer Foundation Retreat (PCF 2019) to discuss PROREPAIR-B. This was an academic prospective observational study evaluating the prevalence and impact of germline mutations in BRCA1, BRCA2, ATM and PALB2 on metastatic castration-resistance prostate cancer (mCRPC) outcomes. Biographies: Elena Castro, MD, Prostate Cancer and Genitou...