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- At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC), Maha Hussain presents the optimal treatment sequencing in metastatic castration-resistant prostate cancer (mCRPC). Biographies: Maha Hussain, MD, FACP, FASCO, is the Genevieve Teuton Professor of Medicine in the Division of Hematology-Oncology, Department of Medicine, and the Deputy Director at the Robert H. Lurie Comprehensive Can...
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- Silke Gillessen facilitates the metastatic castration-resistant prostate cancer session discussion during the Advanced Prostate Cancer Consensus Conference (APCCC) 2022 about treatment recommendations for metastatic castration-resistant prostate cancer. Topics covered include chemotherapy decisions regarding docetaxel and cabazitaxel, ADT, AR pathways, clinical trials versus real-world treatment,...
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- At the 2022 Advanced Prostate Cancer Consensus Conference, Johann de Bono presents the role of PARP inhibitors for metastatic castration-resistant prostate cancer (mCRPC) patients focusing on the case for a selected, judicious use of PARP inhibitors in this setting. Biographies: Johann de Bono, MD, PhD, Professor of Cancer Research and a Professor in Experimental Cancer Medicine at The Institute o...
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- Philip Koo and Alicia Morgans discuss the evolving role of nuclear medicine in the multidisciplinary care of patients receiving radium-223 for metastatic CRPC (Castration-Resistant Prostate Cancer). Dr. Koo advocates for the emergence of "nuclear oncology" as the fourth pillar in comprehensive cancer programs, emphasizing the need for enhanced communication and collaboration among medical oncologi...
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- In this conversation, Fred Saad and Alicia Morgans discuss the critical role of bone health in treating patients with metastatic castration-resistant prostate cancer (mCRPC), particularly when using radium. Dr. Saad highlights that while newer cancer treatments like enzalutamide and abiraterone have been effective, they shouldn't overshadow the importance of bone health. He points to the PEACE III...
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- Elena Castro and Joaquin Mateo join Alicia Morgans in a conversation on data related to genetic testing, PARP inhibitors, and the data we saw come out of GU ASCO with the PROpel and MAGNITUDE trials and they discuss how this data impacts the use of PARP inhibitors in castrate-resistant prostate cancer (CRPC). Drs. Castro, Mateo, and Morgans discuss this data in terms of next-generation sequencing...
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- Christopher Wallis and Zachary Klaassen focus this discussion on the article published in The Lancet titled "Pain and health-related quality of life with olaparib versus physician's choice of next-generation hormonal drug in patients with metastatic castration-resistant prostate cancer with homologous recombination repair gene alterations (PROfound)." The authors of this study aimed to assess pain...
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- Alicia Morgans is joined by Frank Schumacher to discuss the study results assessing the association of functional outcomes by decision-making approaches in men with metastatic prostate cancer. Dr. Schumacher and colleagues assessed the association of shared decision-making vs. physician- or patient-directed decisions and measurement of patient quality of life, including patient-reported functional...
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- Axel Merseburger joins Alicia Morgans to discuss the results from the PRESIDE study presented at ASCO GU 2022. PRESIDE is a randomized, double-Blind, placebo-controlled, Phase 3b study of the efficacy and safety of continuing enzalutamide in chemotherapy-naïve, mCRPC patients treated with docetaxel plus prednisolone once they have progressed on enzalutamide. Clinical data demonstrate that using do...
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- In this discussion between Kara Maxwell and Alicia Morgans, Dr Maxwell highlights the role of TP53 in cancer and understanding the Li-Fraumeni syndrome. Inherited germline TP53 pathogenic and likely pathogenic variants (gTP53) cause autosomal dominant multicancer predisposition including Li-Fraumeni syndrome and the work that Drs. Morgans and Maxwell discuss here sought to determine whether gTP53...
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