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- At the 26th Annual Prostate Cancer Foundation Scientific Retreat (PCF 2019), Professor June Chan joins Charles Ryan to discuss her work with patients on active surveillance (AS) for prostate cancer and a current ongoing study of lifestyle modification. Early data suggest that exercise after diagnosis could help with delaying or deterring prostate cancer recurrence or progression. The AS RCT study...
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- Matthew Cooperberg discusses active surveillance as the standard of care for men with low-risk prostate cancer as well as data from multiple registries including CaPSURE, MUSIC, AQUA, and SEER, which report increasing rates of active surveillance in men with low-risk disease. He further discusses the factors that may be driving lower uptake of active surveillance in some practices. Biographies: Ma...
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- Benjamin Lowentritt and Alicia Morgans discuss the ProVent trial, the use of sipuleucel-T in newly diagnosed prostate cancer patients on active surveillance. They discuss inclusion criteria, trial design and primary outcome measures which include assessing the efficacy of sipuleucel-T in reducing reclassification to a higher Gleason grade in patients on active surveillance. Biographies: Alicia Mor...
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- Lorelei Mucci and Alicia Morgans discuss the findings of a large epidemiologic study examining physical activity and its influence on a wide range of biological processes including anti-inflammatory and insulin pathways, may be linked to a lower risk of prostate cancer. In addition to being one of the largest of its kind, the study stands out in that researchers were able to examine medical record...
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- (Length of Discussion: 20 min) Herb Lepor presents the current optimal management of localized prostate cancer including an in-depth review of focal ablation. He highlights technique, criteria for appropriate patient selection, and the value of counseling to managing expectations. Biography: Herbert Lepor, MD, Professor, Department of Urology, Professor, Department of Biochemistry and Molecular Ph...
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- (Length of interview: 16 min) Mike Harrison and Chuck Ryan dialogue on the specifics of the EXTEND trial. This is a phase 2 trial evaluating the safety and efficacy of exercise training in men receiving enzalutamide plus conventional ADT for hormone naïve prostate cancer. The discussion ensues to the value of exercise in this patient population and some of the nuances in managing patients in this...
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- Sigrid Carlsson, MD talks with Alicia Morgans, MD about long-term outcomes of active surveillance for prostate cancer, a 17-year experience with active surveillance at the Memorial Sloan Kettering Cancer Center. A study which Carlsson was a co-author on and was presented at the most recent American Urological Association meeting (AUA2018). This was a retrospective analysis of all patients managed...
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- J Kellogg Parsons MD, talks with Alicia Morgans prior to his presentation of The Men’s Eating and Living (MEAL) Study (CALGB 70807 [Alliance]): A Randomized Clinical Trial of a Diet Intervention in Men on Active Surveillance for Prostate Cancer at the 113th Annual Scientific Meeting of the American Urological Association (AUA) . A much-anticipated presentation of work assessing the feasibility of...
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- Matthew Cooperberg and Charles Ryan discuss active surveillance in the low risk and low volume disease setting. The topics they highlight include defining the appropriate patient for active surveillance in 2018 and reaching a global consensus, how much age factors into active surveillance, how biomarkers and imaging are driving research and decision making in the active surveillance setting and wh...
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