Localized Prostate Cancer VL

Deciding Against Active Surveillance: How Genomic Testing Impacted Treatment Decision-Making Among a Predominantly African American Population - Peter Gann and Adam Murphy

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Peter Gann and Adam Murphy join Ashley Ross to discuss how the use of the Genomic Prostate Score (GPS) may intersect with patient health literacy to affect decision-making regarding prostate cancer treatment. The discussion begins with an overview of genomics in prostate cancer, particularly the lack of validation of the Oncotype DX assay on African American men. From there, the conversation then...

How Genomic Testing Impacts NCCN Risk Classification of Black Men with Low and Intermediate Risk Prostate Cancer - Andrew Winer

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Andrew Winer and Ashley Ross engage in conversation about critical questions surrounding genomic testing and its impact on active surveillance and NCCN risk classification within the African American population. Dr. Winer points out that prostate cancer transforms into more clinically significant disease, grows faster, and often metastasizes earlier in African American men versus Caucasian men. He...

The ENACT Trial: Ezalutamide Monotherapy plus Active Surveillance vs Active Surveillance Alone in Patients with Low-Risk or Intermediate-Risk Prostate Cancer - Neal Shore

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Neal Shore joins Alicia Morgans in a discussion on the ENACT Randomized Clinical Trial investigating the use of enzalutamide in prostate cancer patients who are starting on active surveillance (AS). They discuss the purpose of the study and Dr. Shore details the study design. There are few published studies prospectively assessing pharmacological interventions that may delay prostate cancer progre...

LuTectomy, a Single-Arm Study of the Dosimetry, Safety, and Potential Benefit of 177Lu-PSMA-617 Prior to Radical Prostatectomy - Declan Murphy & Renu Eapen

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At the 2022 EAU meeting, Declan Murphy presented the initial results of LuTectomy, a single-arm study of the dosimetry, safety, and potential benefit of 177Lu-PSMA-617 prior to radical prostatectomy. Biochemical recurrence rates remain very high for men undergoing either surgery or radiotherapy for localized prostate cancer and no neoadjuvant strategies have succeeded this far in changing that. In...

Incorporating Genomic Testing for Prostate Cancer into Your Practice - Daniel Lin

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Daniel Lin joins Alicia Morgans in highlighting a guideline-directed practical course on how to use genomics in clinical practice. Dr. Lin was part of the instructional course faculty at the AUA annual meeting. The learning objectives of this course include a discussion on the research studies that led to the approval of genomic testing for prostate cancer, ordering appropriate genomic testing bas...

Genomic Risk Classification in Localized Prostate Cancer - Matthew Cooperberg

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Matthew Cooperberg joins Alicia Morgans in a conversation on genomic risk classification in localized prostate cancer. They discuss the risk stratification of prostate cancer and where the use of this is most valuable. Dr. Cooperberg highlights this topic in terms of two basic categories of markers: the pre-diagnostic in terms of liquid tests and post-diagnostic settings. Biographies: Matthew Coop...

Prostate Volume, Baseline Urinary Symptoms, and Their Association with Treatment Choice and Post-Treatment Urinary Function in Men with Localized Prostate Cancer, The CEASAR Study - Daniel Barocas

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Daniel Barocas joins Alicia Morgans in a conversation on the prospective population-based Comparative Effectiveness Analysis of Surgery And Radiation (CEASAR) study which assess rates and predictors of patient-reported treatment regret among men deciding on treatment for localized prostate cancer. The CEASAR Study began accruing patients in 2010 and has a population-based cohort of almost 3000 men...

Barriers and Opportunities in Active Surveillance, HIFU, and Focal Therapy in Latin American Countries - Laurence Klotz

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Laurence Klotz joins Phillip Koo at the 13th International Uro-Oncology Congress in São Paulo, Brazil in a discussion on Active Surveillance (AS), High-intensity focused ultrasound (HIFU), and focal therapy in Latin America and developing countries. There are challenges with active surveillance in developing countries that might not have formal prostate cancer screening programs, a lack of resourc...

Active Surveillance for Patients With Intermediate-Risk Prostate Cancer - Stacy Loeb

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Alicia Morgans is joined by Stacy Loeb to discuss her presentation at the 2022 American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium on the risks and the benefits of active surveillance in the intermediate-risk population. Over the last several years, there has been an increase in the utilization of active surveillance in the United States for patients with intermediate r...

Novel Approaches in the Management of High-Risk Prostate Cancer - Ray Manneh Kopp

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The Scientific Director at the Society of Oncology and Hematology from del Cesar, Columbia, Ray Manneh Kopp joins Phillip Koo bringing a global perspective to a discussion on the novel approaches in the management of high-risk prostate cancer. They discuss the diagnosis criteria currently being used, the novelties in the diagnosis, and adjuvant alternatives in this disease. Biographies: Ray Manneh...
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