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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss The Journal of Urology publication on the Phase 2/3 Prospective Multicenter Study of the Diagnostic Accuracy of Prostate-Specific Membrane Antigen PET/CT with 18F-DCFPyL in Prostate Cancer Patients (OSPREY). Prostate cancer staging is critical in multiple steps in the disease continuum, from the initial diagnosis to the...
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- Christopher Wallis and Zachary Klaassen provide insights into the Cancer Treatment Reviews publication Avelumab first-line maintenance in locally advanced or metastatic urothelial carcinoma: Applying clinical trial findings to clinical practice. In the context of metastatic urothelial carcinoma, avelumab has previously been assessed in a large phase 1b study, using avelumab as salvage therapy in t...
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- Christopher Wallis and Zachary Klaassen provide insights into the European Urology publication titled " Curative-intent Metastasis-directed Therapies for Molecularly-defined Oligorecurrent Prostate Cancer: A Prospective Phase II Trial Testing the Oligometastasis Hypothesis " in this UroToday Journal Club. The question that the authors sought to assess is if data could be derived assessing whether...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen provide insights into the JAMA Oncology publication titled Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial. The management of patients with localized and recurrent prostate cancer is driven predominantly at this point by cli...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen provide insights into the NEJM publication titled Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma from the EV-301 trial. Zachary and Chris discuss the background on enfortumab vedotin, the trial design, methods, results, and conclusions. In light of recent data supporting maintenance treatment with avelum...
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- Testicular cancer survivors may experience mental illness as a consequence of their cancer diagnosis and treatment. A recently published article titled, "Long-Term Mental Health Service Utilization Among Survivors of Testicular Cancer: A Population-Based Cohort Study" focuses on survivorship care plans for testicular cancer patients. In this UroToday Journal Club, Christopher Wallis, MD, Ph.D., an...
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- In this Journal Club video presentation, Christopher Wallis, MD, PhD, and Zachary Klaassen, MD describe a Clinical Genitourinary Cancer publication Treatment Patterns and Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer in a Real-world Clinical Practice Setting in the United States. The primary objective of this analysis is to describe real-world treatment patterns, includ...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the recently published article in the Lancet Oncology, "Stereotactic ablative body radiotherapy in patients with oligometastatic cancers: A prospective, registry-based, single-arm, observational, evaluation study." Patients with oligometastatic disease have a more favorable prognosis than those with widespread metastati...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss an analysis of risk, racial disparity, and outcomes among United States patients with cancer and COVID-19 infections. In this case-control study, patients with cancer were at significantly increased risk for COVID-19 infection, which was further exacerbated among African Americans, highlighting the need to protect and m...
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- In this Journal Club, Christopher Wallis and Zachary Klaassen review the September 2020 publication The Lancet Oncology: Durvalumab Alone and Durvalumab plus Tremelimumab Versus Chemotherapy in Previously Untreated Patients with Unresectable, Locally Advanced or Metastatic Urothelial Carcinoma (DANUBE): A Randomised, Open-Label, Multicentre, Phase 3 Trial. DANUBE was conducted at 224 academic rese...
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