Perspectives on Clinical Trial Design in NMIBC - Ashish Kamat
E. David Crawford hosts a discussion with Ashish Kamat on perspectives in clinical trials in non-muscle invasive bladder cancer (NMIBC). He highlights some challenges FDA approved drugs face from trial to trial depending on the grading system used. He reflects on the difficulty that arrises when comparing across different studies because of various grading systems and risk stratification standards from the European Association of Urology (EUA) vs the American Urological Association (AUA).
Ashish Kamat reviews bacillus Calmette-Guérin (BCG) Failure and uses the example of Diagnostic/Surveillance Cystoscopy for patients in which regular white light cystoscopy was performed vs blue light cystoscopy and how comparing between trials allowing one or the other would raise these confounding factors. He concludes with the timing of BCG treatment factors and notes importance of considering maintenance vs induction treatment and how initial treatment can show BCG failure much sooner than it should.
E. David Crawford
Definitions, End Points, and Clinical Trial Designs for Non–Muscle-Invasive Bladder Cancer: Recommendations From the International Bladder Cancer Group
Myths and Mysteries Surrounding Adjuvant Therapy for NMIBC - Ashish Kamat
Center of Excellence Bladder Cancer