Bladder Cancer VL

RETAIN Trial: A New Hope for Avoiding Cystectomy in Bladder Cancer - Phillip Abbosh

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Ashish Kamat engages Phillip Abbosh to explore cutting-edge research in bladder cancer. Dr. Abbosh highlights the ongoing RETAIN trial, which examines the safety and feasibility of avoiding cystectomy for patients with muscle-invasive bladder cancer who achieve a complete pathologic response post-neoadjuvant chemotherapy. The trial has enrolled 78 subjects and is awaiting mature data. Alongside, D...

Urethral Recurrence after Radical Cystectomy for Bladder Cancer - Ekaterina Laukhtina

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Ekaterina Laukhtina and Ashish Kamat discuss urethral recurrence after radical cystectomy. Dr. Laukhtina goes into depth on using urethroscopy to diagnose urethral recurrence as well as when urethrectomy may be useful highlighting a systematic review and meta-analysis assessing the incidence and risk factors of urethral recurrence as well as summarizing data on survival outcomes in patients with u...

The Role of Bladder-Sparing Trimodality Therapy - Sophia Kamran

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Sophia Kamran joins Sam Chang to discuss her presentation from the GU ASCO 2022 Annual Meeting focusing on novel therapies in bladder cancer and their toxicities, discussing the role of bladder-sparing trimodality therapy with a focus on toxicity and functional outcomes. Biographies: Sophia C. Kamran, MD, Assistant Professor of Radiation Oncology, Harvard Medical School, Massachusetts General Hosp...

Biological Pathways in Urothelial Carcinoma - Carissa Chu

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Carissa Chu joins Sam Chang to discuss data on genetic changes and alterations in urothelial carcinoma. The purpose of the study is to characterize human epidermal growth factor receptor 2 (HER2) (ERBB2) and fibroblast growth factor receptor 3 (FGFR3) mutations in a prospectively collected cohort of urothelial cancers. Dr. Chu highlights the key findings from this study. Biographies: Carissa Chu,...

Treating Women with Bladder Cancer and a Community Approach to Navigating a Diagnosis - Jeannie Hoffman-Censits & Elizabeth Guancial

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Alicia Morgans is joined by Jeannie Hoffman-Censits and Elizabeth Guancial to discuss the challenges women face navigating a bladder cancer diagnosis. In 2022, the American Cancer Society estimates more than 81,000 will be diagnosed with bladder cancer in the United States. Of those, 61,700 will be men, and 19,480 will be women. Drs. Morgans, Hoffman-Censits, and Guancial discuss the importance of...

'BCG-Exposed' Definition Aims to Improve Bladder Cancer Care - Peter Black

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Ashish Kamat and Peter Black delve into a new term, 'BCG-Exposed', in high-risk non-muscle-invasive bladder cancer. Published by the International Bladder Cancer Group, the definition sheds light on this gray area, aiming to enhance clinical trial design and regulatory processes. Dr. Black's publication explores the intricacies of various disease states associated with BCG (Bacillus Calmette-Guéri...

Comparative Effectiveness of Radical Cystectomy and Trimodality Therapy for Muscle-Invasive Bladder Cancer – Boris Gershman

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In a discussion hosted by Ashish Kamat, Boris Gershman presents his study comparing radical cystectomy and trimodality therapy for muscle-invasive urothelial carcinoma of the bladder. The study aims to fill a significant knowledge gap, as no randomized trials have directly compared these treatments. Using an emulation framework to replicate the UK's SPARE trial, which closed due to low recruitment...

Research in Biomarkers for Bladder Cancer - The BCAN Young Investigator Awards - Benjamin Miron

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Benjamin Miron, a 2021 recent recipient of the Bladder Cancer Advocacy Network's (BCAN) Young Investigator Award joins Alicia Morgans to speak about the Young Investigator Award Program. Dr. Miron speaks on the importance of this program and the opportunity it provides young investigators to jumpstart their careers. This funding Dr. Miron received helped to investigate new biomarkers for bladder c...

Quality of Life for Patients Undergoing Radical Cystectomy - Bernard Bochner

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Ashish Kamat is joined by Bernard Bochner to discuss patient quality of life after a radical cystectomy. Dr. Bochner highlights a number of factors that can be affected by having a radical cystectomy which is a significant surgery. Drs. Kamat and Bochner offer insights on assembling a team to assure the best quality of life for these patients. Biographies: Bernard H. Bochner, MD, FACS, Attending S...

Role of Blue Light Cystoscopy in Detecting Invasive Bladder Tumor - Sia Daneshmand

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Siamak (Sia) Daneshmand joins Ashish Kamat in a discussion on the role of blue-light cystoscopy (BLC) in detecting invasive bladder tumors. Providing background on the beneficial use of BLC in carcinoma in situ (CIS), Dr. Daneshmand highlights the evidence on the potential of finding additional TA tumors with the use of BLC. He showcases data from a BJUI multi-institutional registry publication on...