Bladder Cancer VL

Update on Bladder Cancer, Current Trials and Treatments - Bishoy Faltas

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(Length of Presentation: 10 min) Alicia Morgans, MD and Bishoy Faltas, MD have an energetic conversation about the tremendous progress they have seen in the recent years in bladder cancer. Dr. Faltas takes us through some of the current research with IO therapy, specifically checkpoint inhibition; where they are currently used and where the clinical data may expand the use of these agents. He revi...

CARMENA in mRCC and Surgical Management Cases in Bladder Cancer from ASCO 2018 - Tom Keane

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(Length of Discussion: 30 min) Tom Keane, MBBCh, FRCSI, FACS provides a detailed overview of the CARMENA study, presented by Arnaud Mejean MD, Ph.D. at ASCO 2018. This Phase III randomized trial assessed the utility and timing of CNx in the treatment paradigm of mRCC comparing patients who were randomized to either CNx and sunitinib vs sunitinib alone without CNx. He discusses the clinical applica...

Updates in Advanced Urothelial Carcinoma - Highlights from ASCO 2018 - Petros Grivas

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(Length of Discussion: 23 min) Petros Grivas and Alicia Morgans talk post-ASCO 2018 about a number of studies and abstracts presented. The first they review is the ABACUS study presented by Thomas Powles, MD. This single arm, phase II study investigated two cycles of atezolizumab (1200mg every three weeks) prior to radical cystectomy among patients with T2-4N0M0 urothelial carcinoma. The second st...

FDA ALERT: Efficacy Issue Identified in Some Patients Taking Pembrolizumab or Atezolizumab as Monotherapy to Treat Advanced Urothelial Cancer - Petros Grivas

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(Length of Discussion: 16 min) Petros Grivas and Alicia Morgans discuss the late-breaking FDA Alert announcing the label changes for Pembrolizumab and Atezolizumab as Monotherapy to Treat Urothelial Cancer with Low Expression of PD-L1. Biographies: Petros Grivas MD, Ph.D. a medical oncologist at Seattle Cancer Care Alliance with expertise in genitourinary cancers such as bladder cancer, prostate c...

Long-term Efficacy with Atezolizumab an IO Update- Arjun Balar

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(Length of conversation: 14 minutes) Alicia Morgans and Arjun Balar converse on the long-term efficacy data of atezolizumab in the 1st line setting as well as the 2nd line setting from the single-arm phase 2 trial. Discussion evolves to the recent safety alerts by the FDA highlighting the two studies, Keynote 361 and IMvigor 130. They question the applicability to clinical practice and the challen...

Journey from Oncologist to Cancer Survivor and Patient Advocate - Burton Needles

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(Length of Discussion: 12 min) Medical oncologist, bladder cancer survivor, and author of Journey from Oncologist to Cancer Survivor and Patient Advocate in the Era of Precision Medicine, Burt Needles who was diagnosed with a rare form of bladder cancer, plasmacytoid variant in 2013, talks with Alicia Morgans about his unique perspective as a medical oncologist and clinician to a cancer survivor a...

Setting the Stage for the BCG Unresponsive Population - Interview with Ashish Kamat

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(Length of Discussion: 11 min) Ashish Kamat, MD, MPH and Alicia Morgans, MD discuss non-muscle invasive bladder cancer, where the field stands particularly for BCG refractory patients and the definition of the BCG unresponsive patient. Ashish overviews the efforts of the SUO-CTC Bladder Committee and important updates and trials in this disease state . Biographies: Ashish M. Kamat, MD Alicia Morga...

Helping Patients Cope after Major Interventions for Bladder Cancer Therapy

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(Length of Conversation: 17 min) Stephen Williams and Ashish Kamat discuss the paper, Impact of Psychiatric Illness on Decreased Survival in Elderly Patients with Bladder Cancer in the United States, a study which addresses problems that bladder cancer patients face and the difficulties they experience coping after major interventions for bladder cancer therapy. The conversation also includes reco...

The State of Advanced Bladder Cancer - New Data from AACR 2018 - Interview with Arjun Balar

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(Length of Discussion: 30 min) Arjun Balar, MD overviews his presentation from the American Association for Cancer Research Annual Meeting (AACR 2018) meeting on durvalumab plus tremelimumab, combination data in patients with metastatic urothelial cancer. A phase I, Study 10, of data which shows clinical activity with combination treatment in 2nd-line metastatic urothelial carcinoma. A study desig...

The Changing Landscape in Advanced Bladder Cancer - Tom Keane

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(Length of Discussion: 16 min) Dr. Tom Keane discusses the rapidly changing landscape in advanced bladder cancer with the introduction of immune checkpoint inhibitors. To begin his discussion he references a presentation by Thomas Powles, MD from the 2018 ASCO GU meeting where Dr. Powles provided an overview of immune checkpoint inhibitors in urothelial carcinoma at the current time and Dr. Powles...