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- Manish Patel joins Sam Chang to discuss the development of centers of excellence for the treatment of major urological cancers, specifically focusing on radical cystectomy. He explains how the UK's centralization of radical cystectomy in 2002 led to significant improvements in care and better survival rates. In Australia, 50 centers were doing radical cystectomies, but 39 were doing less than four...
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- Ewan Gibb, a PhD scientist, discusses the Decipher Bladder clinical test, a molecular subtyping assay for bladder cancer that predicts the risk of upstaging, identifies high-risk neuroendocrine-like disease and determines the benefit from neoadjuvant chemotherapy. The test breaks a patient's tumor into one of five subtypes and recognizes luminal and non-luminal categories, with neuroendocrine bein...
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- Ashish Kamat and Kari Tikkinen discuss guidelines on thromboprophylaxis in urological surgery. Dr. Tikkinen gives a step-by-step guide through deciding to use thromboprophylaxis, starting with demonstrating that prophylaxis works and then discussing what constitutes a need for thromboprophylaxis for the patient. They also discuss cases where the guidelines may falter and how to troubleshoot in tho...
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- Niyati Lobo joins Ashish Kamat in a conversation about the updated European Association of Urology (EAU) prognostic risk groups and whether or not the updates appropriately consider patients treated with BCG. Dr. Lobo discusses the applicability of the updated groups in a contemporary cohort of non-muscle-invasive bladder cancer (NMIBC) patients at MD Anderson treated with bacillus Calmette-Guérin...
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- Tamer Aboushwareb, Vice President of Medical Affairs, Pacific Edge, Ltd provides an overview of the Cxbladder Monitor urine-based cancer surveillance test and is joined by Neal Shore and Josh Meeks for a discussion on the clinical implications of the use of this test. Several supportive publications are highlighted and Drs Shore, Meeks, and Aboushwareb discuss the Cxbladder Monitor algorithm, its...
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- Hikmat Al-Ahmadie and Olivier Elemento join Ashish Kamat to discuss the data on artificial intelligence in cancer, with specific reference to bladder cancer. The discussion includes an overview of the benefits of using AI and deep machine learning to predict tumor types, responses, and diagnoses. The conversation addresses how automation and digitization intersect well with pathology. However, cur...
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- Nicholas James joins Alicia Morgans in a discussion of the first results of the novel BladderPath trial examining the role of magnetic resonance imaging (MRI) for bladder cancer staging. BladderPath is a randomized comparison of the time from the initial diagnosis to “correct” treatment among patients with possible muscle-invasive bladder cancer who receive staging with MRI, compared to TURBT. Nic...
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- Tamer Aboushwareb, Vice President of Medical Affairs, Pacific Edge, Ltd provides an overview of the Cxbladder Detect urine-based cancer diagnostic test and is joined by Neal Shore and Josh Meeks for a discussion on the clinical implications of the use of this test which is designed for high-risk patients who present with hematuria. Cxbladder is a suite of non-invasive, urine-based laboratory tests...
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- Petros Grivas and Vadim Koskin discuss an investigator-initiated trial of imaging across solid malignancies. A novel way of imaging cancer. Fibroblast activation protein-α (FAP) is a transmembrane protein overexpressed on cancer-associated fibroblasts (CAFs), and instead of imaging cancer cells themselves, this images cells that are present in cancer. These scans label fibroblast activation protei...
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- Anne Schuckman and Alicia Morgans discuss the unique challenges and opportunities for women in urologic oncology. The two explore their own journeys in the field and provide suggestions on how young women seeking a career in urologic oncology can build their careers with confidence. Biographies: Anne K. Schuckman, MD, Director, LAC+USC Urologic Oncology, Keck Hospital of USC, USC Norris Cancer Hos...
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