The Effects of 24-Hour Urinary Calcium Oxalate Supersaturation Level on Stone Growth and New Stone Formation: "When To Worry, When to Not" Presentation - Antonio R. H. Gorgen

May 29, 2023

Antonio Gorgen presents a study that examines the relationship between 24-hour urinary calcium oxalate supersaturation levels and stone growth. The study reviewed 34 patients who underwent renal CT scans and urine evaluations. Findings showed that 77% of patients experienced stone growth, correlating with increased calcium oxalate supersaturation levels. The research suggests that efforts should be made to lower the calcium oxalate supersaturation level to 4 or below in individuals prone to calcium oxalate stone formation.


Biography:

Antonio R. H. Gorgen, Department of Urology, University of California, Irvine, CA

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Antonio R. H. Gorgen: Dear Viewer, I'd like to present our work on the effects of 24-hour urinary calcium oxalate supersaturation level on stone growth and new stone formation: when to worry, when to not.

We sought to determine the relationship between 24-hour urinary calcium oxalate supersaturation levels and CT-documented stone growth. We reviewed 34 patients who had two renal CT scans and two 24-hour urine evaluations within four months of each scan. We calculated the stone volume using 3D segmentation and contrasted that information with calcium oxalate supersaturation values at each time point.

77% of our patients had stone growth, among whom calcium oxalate supersaturation levels were increased. Using a logistic regression model, we found that for each one point rise in calcium oxalate supersaturation, the risk of stone growth increased by 1.5 times.

In conclusion, among calcium oxalate stone formers, efforts should be expended to reduce the calcium oxalate supersaturation level to 4 or less.

Thank you very much.