Advanced Prostate Cancer VL

Final Overall Survival Analysis of the PROSPER Trial in Nonmetastatic Castration-Resistant Prostate Cancer - Karim Fizazi

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Speaking with Alicia Morgans, Karim Fizazi discusses the final overall survival analysis of the PROSPER study in nonmetastatic castration-resistant prostate cancer. Enzalutamide has previously been shown to postpone the time to metastasis or death. Data presented at ASCO 2020 demonstrated that overall survival is significantly improved in patients receiving enzalutamide — median overall survival w...

PROSPER Trial: Significant Improvement in Metastasis-Free Survival (MFS) and Overall Survival (OS) Demonstrated Nonmetastatic Castration-Resistant Prostate Cancer Patients - Fred Saad

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Fred Saad joins Alicia Morgans to discuss the updated data from the PROSPER trial of enzalutamide for nonmetastatic castration-resistant prostate cancer. The updated results show that enzalutamide not only improves metastasis-free-survival, as was indicated by the results published in 2018 but also significantly extends overall survival. Biographies: Fred Saad, MD, FRCS, Professor and Chief of Uro...

PROSPER Trial Journal Club: Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer - Zachary Klaassen and Christopher J.D. Wallis

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In this Journal Club, Zachary Klaassen and Christopher Wallis review the recently published New England Journal of Medicine article Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer, the double-blind, phase 3 PROSPER trial. Men with nonmetastatic, castration-resistant prostate cancer (defined on the basis of conventional imaging and a PSA doubling time of ≤10 months)...

Journal Club: Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer - Zachary Klaassen

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Christopher Wallis and Zachary Klaassen host this journal club on "Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer," published by the HERO trial investigators in the New England Journal of Medicine simultaneously with the first presentation of the trial results at the ASCO 2020 annual meeting. Sharing background information on androgen deprivation therapy (ADT), as well...

HERO Phase III Trial: Results Comparing Relugolix, an Oral GnRH Receptor Antagonist Vs. Leuprolide Acetate for Advanced Prostate Cancer - Neal Shore

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Relugolix is the first oral GnRH receptor antagonist, which was previously shown to rapidly suppress testosterone levels. Neal Shore joins Alicia Morgans to discuss the results of the HERO phase 3 trial comparing the safety and efficacy of relugolix with leuprolide acetate in advanced prostate cancer patients. Relugolix is an oral, once a day medication, and the trial had a primary endpoint of non...

Low Carbohydrate Diets in Men with Recurrent Prostate Cancer: The CAPS2 Study - Stephen Freedland

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Stephen Freedland joins Alicia Morgans to discuss the Carbohydrate and Prostate Study 2 (CAPS2), a randomized controlled trial of a 6-month low carbohydrate intervention on disease progression in men with recurrent prostate cancer. This study is part of a series of studies looking at the role of low carbohydrate diets in prostate cancer. The study involved taking men with rising PSA after failed s...

Supportive Therapy in Androgen Deprivation (STAND) - Rahul Aggarwal

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Charles Ryan sits down with Rahul Aggarwal to discuss one of the first of its kind, the UCSF STAND (Supportive Therapy in Androgen Deprivation) Clinic providing comprehensive care to men with prostate cancer who are receiving androgen deprivation therapy (ADT). While ADT is extremely effective, it causes side effects, including fatigue, hot flashes, and sexual changes, such as decreased libido (se...

An Update on the PRONOUNCE Trial, Comparing the Occurrence of Major Adverse Cardiovascular Events in Patients with Prostate Cancer and Cardiovascular Disease - Susan Slovin

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Susan Slovin joins Alicia Morgans to provide an update on the PRONOUNCE trial, the first Phase III prospective trial comparing a GnRH antagonist with a GnRH agonist with the endpoints of major adverse cardiovascular events. It explores how cardiovascular disease is not only affecting our patient's wellbeing on androgen deprivation therapy but also gives us for the first time a lot of different end...

The Changing Landscape for Locally Advanced Prostate Cancer- Maria de Santis

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Maria de Santis and Chuck Ryan share a conversation on the rapidly changing landscape for the treatment of locally advanced prostate cancer. A focus of the discussion centers around the STAMPEDE data demonstrating benefit with the early use of abiraterone and the use of radiation. They also discuss the role of docetaxel in this evolving environment based on data from both STAMPEDE and CHAARTED dat...

Advancing Prostate Cancer Research - The Prostate Cancer Clinical Trials Consortium (PCCTC) - Sarah Wise

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Sarah Wise, the Director of Research Operations at the Prostate Cancer Clinical Trials Consortium (PCCTC) sits down with Alicia Morgans to talk about the PCCTC, what the goals of the organization are, the benefit of the organization to patients, and how physicians, clinicians, and researchers can support what they are trying to do. The Prostate Cancer Clinical Trials Consortium (PCCTC) was initiat...