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- In this episode of Kidney Cancer Today, Bradley McGregor joins Monty Pal and Jaime Landman to speak about the major practice-changing studies that have come out over the past year in the frontline setting and the evolution of therapy in the renal cell carcinoma space. Biographies: Bradley McGregor, MD, Clinical Director, Senior Physician, Instructor in Medicine, Lank Center for Genitourinary Oncol...
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- Rana McKay and Monty Pal share in a discussion on the study design and results of a phase II study of atezolizumab and bevacizumab in non-clear cell renal cell carcinoma (nccRCC) and clear cell renal cell carcinoma with sarcomatoid differentiation. Biographies: Rana R. McKay, MD, Medical Oncologist, Assistant Professor of Medicine, UC San Diego Health Sumanta Kumar Pal, MD Associate Clinical Profe...
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- Darren Feldman, MD, and Alicia Morgans, MD, MPH, discuss the nuances of treating non-clear cell kidney cancer, a disease that has historically been underrepresented in phase 3 clinical trials of kidney cancer and is also histologically heterogeneous. This heterogeneity makes variations of the disease rare, and thus single-agent VEGF Tyrosine Kinase Inhibitors (TKIs) aren't always effective. Dr. Fe...
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- Che-Kai Tsao, MD, and Alicia Morgans, MD, MPH, sit down to discuss emerging therapeutic options for kidney cancer, specifically focused on patient groups that haven’t historically qualified for targeted treatments. Dr. Tsao highlights a new wealth of treatment options, honing in on checkpoint inhibitors for metastatic kidney cancer — specifically clear cell — and reviewing ongoing and accruing tri...
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- In this episode of Kidney Cancer Today, Jaime Landman helps Monty Pal dissect some of the biggest issues on active surveillance for renal cell carcinoma. The following questions were discussed. Who is the right patient for active surveillance? Can a T1b patient be a candidate for active surveillance? What are the best clinical practices post five years after resection in the surveillance setting?...
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- Shaan Dudani joins Monty Pal and Jaime Landman, sharing an overview of the First-line Immuno-Oncology Combination Therapies in Metastatic Renal-cell Carcinoma: Results from the International Metastatic Renal-cell Carcinoma Database Consortium which was published this past August in European urology. Using the International Metastatic Renal-cell Carcinoma Database Consortium (IMDC) dataset, patient...
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- Alicia Morgans and David Braun discuss his innovative research in metastatic kidney cancer which focuses on understanding and improving immunotherapies in kidney cancer. His work utilizes immunogenomic approaches to generate mechanisms of response and resistance to existing immunotherapies. He is working to develop novel immune-based treatments. David’s key talking points are driven from the thoug...
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- Tian Zhang, MD and Monty Pal, MD review first-line therapy options for metastatic renal cell carcinoma (mRCC), including immunotherapy- based ipilimumab, nivolumab, pembrolizumab, axitinib, as well as avelumab/axitinib combinations and cabozantinib monotherapy. Tian continues focusing on achieving a complete response rate, and treating intermediate, poor-risk disease where she describes an excitin...
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- Monty Pal joins Petros Grivas to share highlights from his ASCO 2019 presentation on IMmotion150, a phase two clinical trial in kidney cancer looking at patient-reported outcomes, that compared monotherapy with atezolizumab, to sunitinib, to the combination of bevacizumab with atezolizumab, a unique opportunity to look at monotherapy in this setting. Biographies: Sumanta Kumar Pal, MD , Associate...
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- Tian Zhang and Alicia Morgans discuss the three new approvals for the first line treatment of metastatic renal cell carcinoma, including cabozantinib with targeted agents, IO combinations with ipilimumab and nivolumab and now the recent approval of pembrolizumab plus axitinib. Dr. Zhang reviews the long-term follow-up from the CHECKMATE-214 study along with the CABOSUN data. The discussion conclud...
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