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- Alicia Morgans speaks with Petros Grivas to discuss the intricacies of the SWOG 1806 clinical trial, led by Dr. Parminder Singh. This multi-institutional study aims to evaluate the efficacy of adding atezolizumab, an anti-PD-L1 agent, to chemoradiation treatment in patients with localized muscle-invasive urothelial carcinoma. Dr. Grivas emphasizes the collaborative nature of this "Herculean effort...
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- Alicia Morgans is joined by Petros Grivas to discuss a unique study focusing on patients with variant histologies of bladder cancer. The study aims to improve complete response rates by combining chemotherapy with pembrolizumab in a neoadjuvant setting. With only 17 patients, it's a pilot study that tackles the difficulty in finding effective treatments for varying histologies such as squamous cel...
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- In this conversation, Alicia Morgans, MD MPH, Neeraj Agarwal, MD, and Petros Grivas, MD, PhD discuss the clinical trial findings from the JAVELIN Bladder 100 trial and how-to treat with chemotherapy followed by avelumab maintenance. They highlight the importance of this to the treatment algorithm of metastatic urothelial carcinoma and highlight a recent publication in Cancer Treatment Reviews on a...
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- In February 2021 AstraZeneca announced the voluntary withdrawal of the Imfinzi (durvalumab) indication in the US for previously treated adult patients with locally advanced or metastatic bladder cancer. In March 2021, Genentech announced the voluntary withdrawals of Tecentriq® (atezolizumab) for the treatment of prior-platinum treated metastatic urothelial carcinoma. Petros Grivas and Alicia Morga...
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- Alicia Morgans is joined by Brenda Martone to discuss the transformative impact of the JAVELIN Bladder 100 trial data on the treatment of unresectable locally advanced or metastatic urothelial carcinoma. The data reveals that patients who receive maintenance avelumab post-chemotherapy experience a significant improvement in overall survival. The conversation delves into the operational aspects of...
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- Currently, the standard of care for muscle-invasive bladder cancer is neoadjuvant chemotherapy followed by radical cystectomy. Patients with residual disease after neoadjuvant chemotherapy have an especially poor prognosis. Unfortunately, there's no standard adjuvant therapy for these patients. Andrew Lenis joins Ashish Kamat emphasizing that additional therapeutic options are needed, and understa...
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- Alfred Witjes, MD, PhD, a member of the international multidisciplinary panel of bladder cancer experts for the European Association of Urology (EAU) Guidelines on muscle-invasive and metastatic bladder cancer joins Ashish Kamat, MD, MBBS, in a discussion summarizing the 2020 updated guidelines. Professor Witjes highlights several updates including variant histologies, the best surgical approach f...
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- Cisplatin-based chemotherapy is recommended in both the neoadjuvant and the first-line setting. The inability to predict which patients would respond to chemotherapy, presents a major clinical problem, as there is a significant overtreatment of patients who do not respond. Lars Dyrskjøt joins Ashish Kamat to discuss a Nature Communications publication titled, Molecular correlates of cisplatin-base...
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- The anti-PD-L1 avelumab in urothelial carcinoma—A discussion with investigator Dr Andrea Apolo. The JAVELIN Solid Tumor phase 1, open-label, dose-escalation trial investigated avelumab, a human monoclonal anti-PD-L1 antibody (anti-PD-L1), in patients with selected tumor indications (eg, NSCLC, breast cancer, colorectal cancer). Pooled analysis of two JAVELIN cohorts that included patients with adv...
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- Beyond Endpoints: An interview with Dr Srikala Sridhar, study chair of the BL12 trial Investigator-initiated trials (IITs) often tackle important questions that are not addressed elsewhere. [transcript] Compared with a pharmaceutical company–managed trials, benefits of IITs include generating data in a real-world setting and resolving issues that confound physicians in daily practice. A recent ope...
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