The effect of rosuvastatin and atorvastatin on erectile dysfunction in hypercholesterolemic patients - Abstract

OBJECTIVE: The aim of this study was to evaluate effect of different statin types on erectile dysfunction in hypercholesterolemic patients.

METHODS: Ninety male hypercholesterolemic patients (mean age 50.4±7.9 years) who are otherwise healthy were included into the study prospectively. None of patients had any cardiovascular risk factors except hypercholesterolemia. Patients were divided into two different groups. One of the groups have received atorvastatin while the other groups was given rosuvastatin. All patients were followed for 6 months and IIEF score and blood samples were re-evaluated.

RESULTS: Patients were in similar ages in both groups. There were also no statistical differences in terms of blood glucose levels, total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and mean IIEF score in both groups at the beginning. After 6 months, no IIEF score changes has been observed in Group-1 after the medication however, IIEF score was significantly lower in Group-2 (p=0.019). There was no difference in IIEF scores between 2 groups after statin therapy.

CONCLUSIONS: It has been suggested that statins may cause ED secondary to inhibition of testosterone synthesis. Rosuvastatin showed no effect on ED while we observed an increased ED with atorvastatin, however there were no difference between both groups. Our study reveals that different statin types may have different effect on ED.

Written by:
Nurkalem Z, Yıldırımtürk O, Ozcan KS, Kul S, Canga Y, Satılmış S, Bozbeyoğlu E, Kaya C   Are you the author?
Bezmialem Vakif University, Faculty of Medicine, Cardiology Department, Istanbul/Turkey.

Reference: Kardiol Pol. 2014 Jan 10. (Epub ahead of print)
doi: 10.5603/KP.a2013.0287

PubMed Abstract
PMID: 24142756 Erectile Dysfunction Section