The Effect of Anti-Muscarinic Agents on Post-Void Residual Urine Volume (PVR) in High Risk Male Patients with Lower Urinary Tract Symptoms (LUTS)



Several studies have demonstrated the efficacy and safety of anti-muscarinics in male patients with lower urinary tract symptoms (LUTS), but few have evaluated their effects on post-void residual urine volumes (PVR) in men at higher risk for developing retention.

Brain Penetration of Trospium Chloride but not of Oxybutynin is Restricted by the Multidrug Resistance Transporter mrd1

ORLANDO, FL ( - Dr. Ira Sharlip, President of the International Society for Sexual Medicine (ISSM) detailed a new definition of premature ejaculation.

Fesoterodine Significantly Improves Treatment Response Rate in Subjects With Overactive Bladder as Early as 2 Weeks: Subpopulation Analyses of a Phase III Trial


Introduction and Objectives: In a previous report of data from this trial, fesoterodine (FESO) was shown to be effective in improving overactive bladder (OAB) symptoms. This subanalysis evaluated the efficacy of FESO as measured by self-reported Treatment Response rates at 2 and 12 weeks in all subjects with OAB and in subpopulations stratified by sex, age, and incontinence status.

Darifenacin Improves Patients’ Perceptions of their Overactive Bladder (OAB) and OAB Symptoms

Introduction and Objectives

The Patient’s Perception of Bladder Condition (PPBC) is a validated measure of a global assessment of treatment benefits (Coyne et al. Eur Urol 2006).

Enhancing Participation of Older Women in Surgical Trials

Introduction and Objective

Recruiting and retaining representative numbers of older participants in trials of therapies that will be prescribed for older persons, particularly surgical therapies, is challenging. Our objective was to describe methodologies used for successful recruitment and retention of older participants in two multisite surgical trials.

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