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- Fred Saad joins Alicia Morgans in discussing the association between PSA response and overall survival (OS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) from the phase 3 ARASENS trial. In the ARASENS trial, the combination of darolutamide plus ADT and docetaxel significantly prolonged the time to PSA progression, and more patients receiving darolutamide vs placebo achieved...
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- Cora Sternberg joins Alicia Morgans in a discussion on the treatment landscape of metastatic hormone-sensitive prostate cancer (mHSPC) highlighting the ARASENS trial. The treatment landscape for mHSPC has become increasingly complex during the last several years. The ARASENS study along with PEACE-1 demonstrated that in patients eligible for treatment with chemotherapy, the addition of abiraterone...
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- Alicia Morgans is joined by Tomasz Beer for a discussion on the ARASENS trial. Recently presented at GU ASCO 2022, the ARASENS trial is an international, double-blind, phase 3 study that enrolled patients with metastatic hormone-sensitive prostate cancer (mHSPC) and ECOG performance status 0 or 1. The most important finding was androgen deprivation therapy (ADT) plus docetaxel plus darolutamide pr...
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- Alicia Morgans is joined by Bertrand Tombal who provides a European perspective highlighting prostate cancer data we have seen so far this year starting with the ARASENS and PEACE-1 data. Dr. Tombal's discussion highlights key points for the community to focus on including the messages around maximal androgen blockade and PARP inhibitors. Biographies: Bertrand Tombal, MD, PhD, Chairman of the Depa...
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- Fred Saad, Bertrand Tombal, and Neal Shore join Alicia Morgans in a discussion on the results of the ARASENS trial which examined darolutamide in combination with docetaxel and ADT compared to docetaxel and ADT. They discuss the trial design, its endpoints, how it impacts practice in Canada, the US, and in Europe, and the ideal patient population for this treatment. Biographies: Neal Shore, MD, FA...
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- Christopher Wallis and Zachary Klaassen highlight the New England Journal of Medicine publication on the international, phase 3 ARASENS trial. The primary analysis involved 1306 patients (651 in the darolutamide group and 655 in the placebo group); 86.1% of the patients had disease that was metastatic at the time of the initial diagnosis. At the data cutoff date for the primary analysis (October 2...
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- Joining Alicia Morgans is Matthew Smith to discuss the ARASENS trial presented at GU ASCO 2022. ARASENS is a randomized phase 3 trial of darolutamide versus placebo in combination with docetaxel and androgen-deprivation therapy (ADT) for metastatic hormone-sensitive prostate cancer (mHSPC). Dr. Smith believes that the ARASENS data strongly supports a three-drug regimen of ADT, docetaxel, and an AR...
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- Oliver Sartor joins Alicia Morgans to reflect on prostate cancer data presented during ASCO GU, highlighting data from three studies. Dr. Sartor discusses the phase 3 ARASENS trial, the phase 3 MAGNITUDE study, and the phase 3 PROpel trial. They discuss their perspectives on how these data will inform practice in the future. Biographies: A. Oliver Sartor, MD, Professor of Medicine and Medical Dire...
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- Karim Fizazi joins Alicia Morgans in discussing the ARASENS trial which examined darolutamide in combination with docetaxel and androgen deprivation therapy (ADT) compared to docetaxel and ADT. The ARASENS trial is an international, double-blind, phase 3 study that enrolled patients with mHSPC and ECOG performance status 0 or 1. Drs. Morgans and Fizazi detail the overall survival data presented at...
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