Studies exploring the association of cigarette smoking with long-term survival outcomes following radical cystectomy (RC) have revealed debatable results. We performed a systematic review and meta-analysis to investigate the impact of tobacco smoking exposure, duration, intensity, and cessation on response to neoadjuvant chemotherapy (NACh) and long-term survival outcomes in patients undergoing RC for bladder cancer (BCa)Methods:A systematic search of original articles published up to April 2019 was performed using PubMed, MEDLINE, Embase, and Cochrane Library databases.