OBJECTIVE - PBRM1 is one of the histone and chromatin regulators. A mutation in PBRM1 was recently identified in clear cell renal cell carcinoma (ccRCC). The aim of this study was to determine the clinicopathologic and prognostic significance of PBRM1 expression in ccRCC.
Metastatic renal cell carcinoma (RCC) patients are commonly treated with vascular endothelial growth factor (VEGF) inhibitors or mammalian target of rapamycin inhibitors. Correlations between somatic mutations and first-line targeted therapy outcomes have not been reported on a randomized trial.
SAN FRANCISCO, CA USA (UroToday.com) - Several recently published iterations of the clear cell renal cell carcinoma (ccRCC) genome have demonstrated recurrent mutations in BAP1 and PBRM1. Dr. James Brugarolas presented data regarding the role of these two genes.
SAN FRANCISCO, CA USA (UroToday.com) - The Cancer Genome Atlas (TCGA) version of the clear cell renal cell (ccRCC) genome was published in June 2013, and Dr. Roeland Verhaak presented an update of the original iteration.
The prognostic value of PBRM1 expression in renal cell carcinoma (RCC) had been investigated in previous studies; however, the results remain inconclusive. We investigated the prognostic value and clinicopathological significance of PBRM1 protein expression in RCC.
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