Non-invasive Diagnosis Articles


  • Assessing the Diagnostic Value of Plasma-Free DNA in Prostate Cancer Screening

    Prostate cancer is the second form of cancer among men worldwide. For early cancer detection, we should identify tumors in initial stages before the physical signs become visible. The present study aims to evaluate the diagnostic value of cell-free DNA (cfDNA), its comparison with prostate-specific antigen (PSA) level in prostate cancer screening and also in patients with localized prostate cancer, metastatic form, and benign prostatic hyperplasia (BPH).

    Published February 28, 2018
  • Non-invasive Detection of Clinically Significant Prostate Cancer Using Circulating Tumor Cells.

    PSA testing results in unnecessary biopsy and over-diagnosis with consequent over-treatment. Tissue biopsy is an invasive procedure, associated with significant morbidity. More accurate non- or minimum-invasive diagnostic approaches should be developed to avoid unnecessary prostate biopsy and over-diagnosis.

    Published August 9, 2019
  • Urine cell-based DNA methylation classifier for monitoring bladder cancer.

    Current standard methods used to detect and monitor bladder cancer (BC) are invasive or have low sensitivity. This study aimed to develop a urine methylation biomarker classifier for BC monitoring and validate this classifier in patients in follow-up for bladder cancer (PFBC).

    Published July 13, 2018