Bone metastasis is very common in prostate cancer (PCa) and causes severe pain. PC-3 is an androgen receptor (AR)-negative PCa cell line with high metastatic potential established from PCa bone metastasis.
Tumor epithelial cells undergo a morphological shift through the process of epithelial mesenchymal transition (EMT) with characteristic loss of cell polarity, conferring invasive and metastatic properties during cancer progression.
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