Medullary Sponge Kidney Articles

Articles

  • Breaking the ice: urine proteomics of medullary sponge kidney disease: Beyond the Abstract

    Medullary sponge kidney (MSK) disease is a benign congenital disorder but sometimes leads to significant complications, particularly hematuria, urinary tract infection, and calcium nephrolithiasis. Three pathogenic factors including urinary stasis in the outpouchings (or cysts) of inner medullary collecting duct (IMCD), increased promoters (e.g., hypercalciuria, hyperuricosuria and hyperoxaluria) and decreased inhibitors (e.g., hypocitraturia) contribute to calcium nidus formation and eventually lithogenesis in MSK patients. Evidence of molecular stone pathogenesis in MSK is scant. 
    Published April 28, 2017
  • Breaking the ice: urine proteomics of medullary sponge kidney disease.

    Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinically compatible enzyme-linked immunosorbent assay.

    Published January 16, 2017
  • The impact of kidney stone disease on quality of life in high-risk stone formers.

    To assess the impact of kidney stone disease (KSD) and its treatment on the health-related quality of life (HRQOL) of high-risk stone formers with hyperparathyroidism, renal tubular acidosis, malabsorptive disease, and medullary sponge kidney.

    Published February 12, 2024