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Fluorescence-guided surgery

  • Fluorescence guided surgery and tracer-dose, fact or fiction?

    INTRODUCTION - Fluorescence guidance is an upcoming methodology to improve surgical accuracy. Challenging herein is the identification of the minimum dose at which the tracer can be detected with a clinical-grade fluorescence camera.

    Published April 4, 2016
  • Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo.

    Bladder cancer is the fifth most common in incidence and one of the most expensive cancers to treat. Early detection greatly improves the chances of survival and bladder preservation. The pH low insertion peptide (pHLIP) conjugated with a near-infrared fluorescent dye [indocyanine green (ICG)] targets low extracellular pH, allowing visualization of malignant lesions in human bladder carcinoma ex vivo.

    Published October 5, 2016
  • Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP® peptide ex vivo: Beyond the Abstract

    In modern medicine, we increasingly find ourselves at the interface of technological advances and scientific breakthroughs.  As techniques and instrumentation become ever more precise, research into specific disease processes progressively focuses on unique microscopic and molecular features that might lend themselves as therapeutic target.  Interestingly the mechanisms behind the molecules at work in the study at hand rely on basic cancer biology principles, namely that of tumor acidity and disease microenvironment.  
    Published December 5, 2016