• A new label-free screen for steroid 5α-reductase inhibitors using LC-MS.

    Steroid 5α-reductase (S5αR) plays an important role in metabolizing testosterone into active androgen dihydrotestosterone (DHT) which is involved in many androgen dependent disorders, such as androgenic alopecia, benign prostatic hyperplasia and acne.

    Published October 31, 2016
  • A profile of enzalutamide for the treatment of advanced castration resistant prostate cancer.

    Recent advances in understanding the mechanisms underlying the development and progression of castration resistant prostate cancer from androgen-sensitive prostate cancer have provided new avenues exploring efficacious therapies in a disease which is the second leading cause of cancer deaths among men in the western world.

    Published September 7, 2015
  • Androgen Receptor Signaling in Bladder Cancer.

    Emerging preclinical findings have indicated that steroid hormone receptor signaling plays an important role in bladder cancer outgrowth. In particular, androgen-mediated androgen receptor signals have been shown to correlate with the promotion of tumor development and progression, which may clearly explain some sex-specific differences in bladder cancer.

    Published March 9, 2017
  • Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients.

    Consumption of cruciferous vegetables is associated with a decreased risk of developing prostate cancer. Antineoplastic effects of cruciferous vegetables are attributable to bioactive indoles, most prominently, 3, 3'-diindolylmethane (DIM).

    Published April 22, 2016

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