Urothelial carcinoma (UC) of the upper urinary tract (UUT) is rare, constituting 5% to 10% of UCs, with a higher prevalence in males and older adults. It encompasses various subtypes and, unlike UC of the bladder, often presents as invasive disease. Molecular studies reveal frequent FGFR3 and TP53 mutations, guiding therapeutic strategies. Lynch Syndrome (LS), a hereditary condition, significantly contributes to UUT UC, especially in young patients. Current treatments emphasize platinum-based chemotherapy post-surgery, though immunotherapy shows promise, especially in LS cases. Further molecular insights are crucial for improving diagnosis and treatment.
Surgical pathology clinics. 2024 Sep 25 [Epub]
Compérat Eva, Kläger Johannes, Shariat Shahrokh, Wasinger Gabriel
Department of Pathology, Medical University Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria. Electronic address: ., Department of Pathology, Medical University Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria., Department of Urology, Medical University Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria.