Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study.

The purpose of this study was to identify the significant risk factors of urinary bladder recurrence (UBR) after nephroureterectomy (NUx) in patients with upper tract urothelial carcinoma (UTUC). A total of 550 patients diagnosed with UTUC between January 2001 and December 2015 were included in this retrospective study. The median age of our patients was 68 (range 24-93) and the median follow-up time after NUx was 40.3 months (range 8-191). The most important censored point of this study was the first episode of UBR. Of the 550 patients, UBR occurred in 164 patients (29.8%). One hundred and forty-two (86.6%) patients with UBR were identified within two years after NUx for UTUC, with the median time interval between NUx and UBR being 8.4 months (range 3-59.8). Through univariate analysis, the positive surgical margin (p = 0.049) and tumor multifocality (p = 0.024) were both significant prognostic factors for UBR-free survival after NUx in patients with UTUC. However, only tumor multifocality (p = 0.037) remained a significant prognostic factor by multivariate analysis. In conclusion, tumor multifocality is a significant risk factor of UBR after nephroureterectomy in patients with upper tract urothelial carcinoma.

Diagnostics (Basel, Switzerland). 2020 Apr 03*** epublish ***

Chuan-Shu Chen, Jian-Ri Li, Shian-Shiang Wang, Cheng-Kuang Yang, Chen-Li Cheng, Chi-Rei Yang, Yen-Chuan Ou, Hao-Chung Ho, Chia-Yen Lin, Sheng-Chun Hung, Cheng-Che Chen, Shu-Chi Wang, Kun-Yuan Chiu, Shun-Fa Yang

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan., Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan., Department of Urology, China Medical University Hospital, Taichung 404, Taiwan., Department of Urology, Tung's Taichung MetroHarbor Hospital, Taichung 433, Taiwan.