Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-Based Analysis

To describe epidemiological patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidly in this demographic, yet little is known about TGCTs in Hispanic patients.

We compared patient factors, tumor characteristics, treatment patterns, and outcomes of non-Hispanic white (NHW) vs. Hispanic patients at our own institution in North Texas from 2010-2016. The findings were corroborated by analyzing the National Cancer Database (NCDB) testicular cancer registry from 2004-2014.

We identified 154 patients with TGCT at our institution, of which 89 were NHW (56.0%) and 65 were Hispanic (40.9%). Review of the NCDB identified 49,607 NHW patients (81.5%) and 6,724 Hispanic patients (11.0%) diagnosed with TGCT. At presentation, Hispanic patients were approximately 5 years younger than NHW patients, delay seeking care for testicular cancer, were more likely to have non-seminomatous histology, larger tumor size, and higher disease burden at presentation. Additionally, we identified differences in treatment patterns at the national level.

Differences in outcomes and treatment patterns of Hispanics and NHW with TGCT may represent underlying socioeconomic issues and access to care, however discrepancies in age of onset and histology between TGCT in Hispanics and NHW may signify differences in tumor biology or risk factors. We suggest this possibility be explored further as we embark upon genomic classification of TGCT.

Urology. 2017 Oct 24 [Epub ahead of print]

Solomon L Woldu, Ahmet M Aydin, Ashwin V Rao, Ryan C Hutchinson, Nirmish Singla, Timothy N Clinton, Laura-Maria Krabbe, Niccolo M Passoni, Ganesh V Raj, David S Miller, James F Amatruda, Arthur I Sagalowsky, Yair Lotan, Yull Arriaga, Vitaly Margulis, Aditya Bagrodia

Department of Urology, University of Texas Southwestern Medical Center (Dallas, Texas)., Deparment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center (Dallas, Texas)., Department of Pediatrics, Division of Hematology, and Oncology, University of Texas Southwestern Medical Center (Dallas, Texas)., Department of Internal Medicine, Division of Hematology and Oncology, University of Texas Southwestern Medical Center (Dallas, Texas)., Department of Urology, University of Texas Southwestern Medical Center (Dallas, Texas). Electronic address: .

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