Three cases of thyroid cancer following the diagnosis of testicular cancer: treatment-related complication or genetics?

Large-scale epidemiological studies have shown that the incidence of second primary thyroid cancer in subjects diagnosed and treated for testicular cancer is raised. This finding is strongly associated to treatment with radiotherapy and/or chemotherapy and it is explained by their mutagenic effect.

On the other hand, inherited cancer susceptibility syndromes inducing both testicular and thyroid cancers denote that these tumours might share common genomic aberrations. We herein present our experience with three cases of metachronous development of thyroid cancer after diagnosis and treatment of testicular cancer in our tertiary cancer centre. Our case report contributes to the limited available literature on such findings and aims to raise awareness of the cancer physicians treating these particular tumour types.

Scottish medical journal. 2016 Apr 11 [Epub ahead of print]

Pavlina Spiliopoulou, Sarah Pauline Bowers, Sarah Gibson, Jeff White, Nick Reed

MBBS, MRCP, MSc, Department of Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK MBChB, University of Glasgow, School of Medicine, Glasgow, UK., MSc, Department of Clinical Genetics, Southern General Hospital, Glasgow, UK., MBChB, DM, FRCP, Department of Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Professor, MBChB, FRCR, Department of Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK.

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