[Postchemotherapy residual tumour resection in complex metastatic sites of advanced testicular germ cell tumours]

INTRODUCTION - Postchemotherapy residual tumour resection (PC-RTR) is an integral part of the multimodal therapy for advanced testicular germ cell tumours. Depending on the extent and localisation of the residual mass, PC-RTR may necessitate a multidisciplinary procedure (which should be planned preoperatively), to resolve even complex situations in an oncologically sound manner, with lower treatment-related morbidity The aim of article is to report on the interdisciplinary management of complex residual masses.

PATIENTS AND METHODS - Of a total of 162 patients who underwent PC-RTR, 24 (17. 8 %) patients underwent, in addition to a bilateral postchemotherapy retroperitoneal lymphadenectomy (PC-RPLND), complex adjunctive resections including the abdominal aorta, the inferior vena cava, or the thoracic/lumbar spine, and the neighbouring vessels (n = 15). We performed a retrospective analysis of treatment-associated complications according to the Clavien-Dindo classification and of progression-free, cancer-specific and overall survival.

RESULTS - Median patient age was 24. 5 (18-52) years. All patients had an intermediate or poor prognosis according to the International Germ Cell Cancer Collaboration Group (IGCCCG). Median tumour diameter at the time of surgery was 18. 6 (9. 0-35) cm. In 5 patients 1-2 metastatic lumbar vertebral bodies were completely resected, stabilised and replaced by means of a cage. In 6 patients resection of the abdominal aorta/inferior vena cava with vascular prosthesis replacement was required owing to infiltration. In 2 patients the common iliac artery or vein was resected and replaced. In addition, retrocrural lymph nodes had to be resected in 5 patients and 3 patients required adjunctive nephrectomy. In another 4 patients the Whipple procedure was required owing to infiltration into the pancreas and/or duodenum. The median operating time was 7. 8 (6-15) h, the median blood loss was around 1,450 (900-3,400) ml, and 2 Clavien-Dindo grade IVa complications occurred. Pathohistology revealed teratoma/vital cancer in 16/24 patients and scarring/necrosis in 8 patients. After a median follow-up of 2. 5 years, 1 patient developed recurrent disease and 1 patient died of the disease.

CONCLUSIONS - Postchemotherapy, a few patients with advanced nonseminomas (NS) need complex residual tumour resection in an interdisciplinary setting, with a good functional and oncological outcome. Even the involvement of vascular vertebral structures does not constitute a contraindication for complete resection.

Der Urologe. Ausg. A. 2016 Jan 28 [Epub ahead of print]

P Paffenholz, D Pfister, A Heidenreich

Klinik für Urologie, Universitätsklinikum Köln, Kerpener Str.  62, 50937, Köln, Deutschland. , Klinik für Urologie, Universitätsklinikum Köln, Kerpener Str.  62, 50937, Köln, Deutschland. , Klinik für Urologie, Universitätsklinikum Köln, Kerpener Str.  62, 50937, Köln, Deutschland. 

PubMed