BERKELEY, CA (UroToday.com) - Patients with advanced germ cell tumours may present with metastatic disease at several sites. The occurrence of bone metastases is rare and its true incidence is unknown. Nevertheless, its awareness is important in order to treat patients appropriately, especially since patients with bone metastases at relapse have a dismal outcome with cure rates falling significantly after failed first-line therapy. We present here the largest unselected cohort of bone metastases in patients with germ cell cancer in order to determine typical patient characteristics.
Our analysis is limited in that it is a retrospective analysis of a large patient database, which only allows descriptive and hypothesis-generating analyses, and, in addition, specific data on symptoms related to bone metastases were not routinely entered into the database. Nevertheless, our study suggests the unmet clinical need for a multidisciplinary approach to the treatment of bone metastases in such cases. Further evaluation is required, for example with prospective data collection, in order to better characterize this uncommon event. Such systematic data would help improve our understanding of the risk factors, characteristics, and treatment outcomes of patients with germ cell tumours and bone metastases, and help identify optimal treatment strategies in this rare clinical, but nonetheless important, condition.
Mariam Jamal-Hanjani as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.
Specialist Registrar in Medical Oncology
Great Maze Pond
London, United Kingdom