Lymphonodal, pulmonary and pleural gliomatosis in a 42-year old male with non-seminomatous testicular germ cell cancer - Abstract

A 42 year-old man presented with a localized germ cell tumor (GCT) of the left testicle in February 2010.

Serum tumor markers were normal. After orchiectomy the tumor was staged pT2 N0 M0 L0 V1 S0, clinical stage IB according to UICC criteria. Histopathological examination revealed seminoma and embryonal carcinoma, but no immature teratomatous components were present. Two cycles of adjuvant cisplatin-based chemotherapy were applied. Eighteen months later, he relapsed with enlarged thoracic and abdominal lymph nodes, malignant pleural effusion, liver metastases, and elevated LDH. A liver biopsy showed poorly differentiated carcinoma, which was positive for SALL4 as the only marker indicating a germ cell origin1.

Written by:
Oing C, Wagner R, Bokemeyer C, Honecker F.   Are you the author?
Department of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Eppendorf, Hamburg, Germany.

Reference: Histopathology. 2014 Jan 20. Epub ahead of print.
doi: 10.1111/his.12374

PubMed Abstract
PMID: 24444134 Testicular Cancer Section