Regeneration of spermatogenesis after testicular cancer chemotherapy - Abstract

Purpose: Azoospermia is a common side effect of chemotherapy.

Although most patients restore spermatogenesis over time, the exact time course has not been well described. We analyzed the recovery of spermatogenesis in testicular cancer patients following chemotherapy.

Patients and Methods: 49 patients, consisting of 45 treated with a bleomycin, etoposide and cisplatin (BEP) regimen and 4 with high-dose chemotherapy, were followed up with occasional semen analyses. The primary endpoint of this study was the confirmation of motile spermatozoa in the patients' semen.

Results: Among 45 patients treated with BEP, 44 recovered spermatogenesis. The recovery of spermatogenesis was delayed depending on the increase in BEP cycles. In groups of patients who received 1-2, 3 and 4 cycles, the recovery rates of spermatogenesis within 2 year were 83.3, 80.0 and 66.7%, respectively. In the group with 5-6 cycles of BEP, re-spermatogenesis was significantly delayed and no patients re-established spermatogenesis within 2 years. The patients' age and semen parameters before chemotherapy were not useful as predictive factors for the recovery of spermatogenesis.

Conclusion: The recovery of spermatogenesis was rather fast and was often observed as early as several months after BEP treatment when the number of cycles was < 4.

Written by:
Suzuki K, Yumura Y, Ogawa T, Saito K, Kinoshita Y, Noguchi K.   Are you the author?
Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Reference: Urol Int. 2013 Sep 6. Epub ahead of print.
doi: 10.1159/000351189

PubMed Abstract
PMID: 24021744 Testicular Cancer Section