Testicular cancer in Europe and the USA: Survival still rising among older patients - Abstract

Background: Despite high curability, some testicular cancer (TC) patient groups may have increased mortality.

We provide a detailed age- and histology-specific comparison of population-based relative survival of TC patients in Europe and the USA.

Design: Using data from 12 European cancer registries and the USA Surveillance, Epidemiology and End Results 9 database, we report survival trends for patients diagnosed with testicular seminomas and nonseminomas between 1993-1997 and 2003-2007. Additionally, a model-based analysis was used to compare survival trends and relative excess risk (RER) of death between Europe and the USA adjusting for differences in age and histology.

Results: In 2003-2007, the 5-year relative survival of patients with testicular seminoma was at least 98% among those aged < 50 years, survival of patients with nonseminoma remained 3%-6% units lower.Despite improvements in the relative survival of nonseminoma patients aged ≥50 years by 13%-18% units, survival remained markedly lower than the survival of seminoma patients of the same age. Model-based analyses showed increased RERs for nonseminomas, older, and European patients.

Conclusions: There remains little room for survival improvement among testicular seminoma patients, especially for those aged < 50 years. Older TC patients remain at increased risk of death, which seems mainly attributable to the lower survival among the nonseminoma patients.

Written by:
Verhoeven RH, Gondos A, Janssen-Heijnen ML, Saum KU, Brewster DH, Holleczek B, Crocetti E, Rosso S, Hakulinen T, Aareleid T, Brenner H.   Are you the author?
Eindhoven Cancer Registry/Comprehensive Cancer Centre South, Eindhoven, The Netherlands.

Reference: Ann Oncol. 2012 Oct 30. Epub ahead of print.
doi: 10.1093/annonc/mds460


PubMed Abstract
PMID: 23110807

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