Testicular germ cell tumours: Predisposition genes and the male germ cell niche - Abstract

Sussex Cancer Centre, Royal Sussex County Hospital, Eastern Road, Brighton BN2 5BE, East Sussex, UK.

Molecular Cytogenetics, Male Urological Cancer Research Centre, The Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, Surrey, UK.



Testicular germ cell tumours (TGCTs) of adults and adolescents are putatively derived from primordial germ cells or gonocytes. Recently reported genome-wide association studies implicate six gene loci that predispose to TGCT development. Remarkably, the functions of proteins encoded by genes within these regions bridge our understanding between the pathways involved in primordial germ cell physiology, male germ cell development and the molecular pathology of TGCTs. Furthermore, this improved understanding of the mechanisms underlying TGCT development and dissemination has clinical relevance for the management of patients with these tumours.

Written by:
Gilbert D, Rapley E, Shipley J.   Are you the author?

Reference: Nat Rev Cancer. 2011 Apr;11(4):278-88.
doi: 10.1038/nrc3021

PubMed Abstract
PMID: 21412254

UroToday.com Testicular Cancer Section



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