The aim of this study was to identify epidemiological and histopathological patterns of pediatric testicular tumor (TT) in Saudi population over 10 years.
Retrospective data extracted from the Saudi Cancer Registry for Saudi children diagnosed with TT from 2008 to 2017. The data collected included patient's factors as age, year of diagnosis, survival status, and tumor factors as basis of diagnosis, origin of the tumor, histopathological group and subtype, and tumor behavior, stage, and laterality.
A total of 115 patients with a median age of 14 (IQR 1.5-17) were included. The primary tumor site was a normal descended testis in 98.3% (115). Yolk sac tumor was the most common 28.2% (33), followed by embryonal carcinoma in 27.4% (32) and mixed germ-cell tumors in 23.1% (27). Kaplan-Meier analysis revealed significant association between survival and the stage of the tumor (p = 0.002). However, there was a lack of significant association between survival and age groups, histopathological groups, and histopathological subtypes (p = 0.541, p = 0.609, and p = 0.733, respectively). The overall mortality rate of TT 5.2% with all deaths caused by non-seminomatous germ-cell tumor diagnosed with stage 3.
The median age of the patients was 14 years. Yolk sac tumors were the most common while testicular choriocarcinomas were the least in incidence. No increase in the incidence of TT was seen and the mortality rate over the 10-year period was 5.2%. Shorter survival was associated with higher tumor stage.
International urology and nephrology. 2023 Jul 21 [Epub ahead of print]
Abdullah Mohammed Alkhayal, Meshal Fahad Aljarallah, Muhannad Q Alqirnas, Rakan S Aldusari, Fahad Alyami, Yasser Jamalalail, Hala Hadhoud, Khaled Alrabeeah, Bader H Alsaikhan, Yahya Ghazwani, Yasser A Noureldin
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia., College of Medicine, King Saud University Riyadh, Riyadh, Saudi Arabia., Pediatric Urology Division, King Abdulaziz Medical City, King Abdullah Specialized Children Hospital, National Guard-Health Affiars, Riyadh, Saudi Arabia., Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt., Division of Urology, King Abdulaziz Medical City, Riyadh, Saudi Arabia. .