Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: A population-based case-control study in Connecticut and Massachusetts.

The incidence rate of testicular germ cell tumors (TGCT) has continuously increased in Western countries over the last several decades. Some epidemiologic studies have reported that the endocrine disrupting polychlorinated biphenyls (PCBs) in serum may be associated with TGCT risk, but the evidence is inconsistent. Our goal was to investigate whether serum levels of PCBs are associated with the increase of TGCT risk. We conducted a population-based case-control study of 308 TGCT cases and 323 controls, all residents of Connecticut and Massachusetts. Serum levels of 56 PCBs congeners were measured using gas chromatography and unconditional logistic regression model was used to evaluate the risk of TGCT associated with total PCBs exposure, groups of PCBs categorized by Wolff's functional groups, and individual PCB congeners. The results showed that there was no association between total serum levels of PCBs and risk of TGCT overall (quartile 4 (Q4) vs. quartile 1 (Q1) odds ratio (OR) and 95% confidence interval (C.I.) = 1.0 (0.6-1.9), ρ trend = 0.9). However, strong positive association was observed between total serum levels of Wolff's Group 1 (potentially estrogenic) PCBs and risk of overall TGCT (Q4 vs. Q1 OR = 2.5, 95% CI = 1.3-4.7, ρ trend <0.05) as well as seminoma and non-seminoma subtypes. Wolff's Group 1 PCB congeners that showed an increased risk of TGCT included: 25, 44, 49, 52, 70, 101, 174, and 201/177. Considering the continuing increase of TGCT, these associations should be replicated in different populations with larger sample size.

Environmental pollution (Barking, Essex : 1987). 2021 Jan 11 [Epub ahead of print]

Zhiyuan Cheng, Xichi Zhang, Bryan Bassig, Russ Hauser, Theodore R Holford, Elizabeth Zheng, Dian Shi, Yong Zhu, Stephen Marc Schwartz, Chu Chen, Kunchong Shi, Bo Yang, Zhengmin Qian, Peter Boyle, Tongzhang Zheng

School of Public Health, Brown University, Providence, RI, USA, 02903., Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, 1518 Clifton Rd, NE, Atlanta, GA, USA, 30322., Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA, 20892., Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, MA, USA, 02115., Department of Biostatistics, Yale School of Public Health, Yale University, CT, USA, 06510., University of Vermont, Burlington, VT, USA, 05405., School of Public Health, Brown University, Providence, RI, USA, 02903; School of Basic Medicine, Lanzhou University, Lanzhou, Gansu, 730000, China., Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, 98109., Institute for Global Health & Wellbeing College for Public Health & Social Justice, Saint Louis University, St. Louis, MO, 63103, USA., International Prevention and Research Institute, International Agency for Research on Cancer (IARC), Lyon, 69006, France., School of Public Health, Brown University, Providence, RI, USA, 02903. Electronic address: .

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