A population-based study of testicular cancer risk among children and young adults from Norway and Utah, USA.

Similar family-based cancer and genealogy data from Norway and Utah allowed comparisons of the incidence of testicular cancer (TC), and exploration of the role of Scandinavian ancestry and family history of TC in TC risk. This study utilizes data from the Utah Population Database and Norwegian Population Registers. All males born during 1951-2015 were followed for TC until the age of 29 years. A total of 1,974,287 and 832,836 males were born in Norway and Utah, respectively, of whom 2,686 individuals were diagnosed with TC in Norway and 531 in Utah. The incidence per year of TC in Norway (10.6) was twice that observed in Utah (5.1) for males born in the last period (1980-1984). The incidence rates of TC in Utah did not differ according to presence or absence of Scandinavian ancestry (p=0.669). Having a brother diagnosed with TC was a strong risk factor for TC among children born in Norway and Utah, with HR= 9.87 (95% CI 5.68-17.16) and 6.02 (95% CI 4.80-7.55), respectively; with even higher HR observed among the subset of children in Utah with Scandinavian ancestry (HR=12.30 95% CI 6.78- 22.31). A clear difference in TC incidence among individuals born in Norway and descendants of Scandinavian people born in Utah was observed. These differences in TC rates point to the possibility of environmental influence. Family history of TC is a strong risk factor for developing TC in both populations. This article is protected by copyright. All rights reserved.

International journal of cancer. 2020 Mar 06 [Epub ahead of print]

Ruby Del Risco Kollerud, Hege S Haugnes, Bjørgulf Claussen, Magne Thoresen, Per Nafstad, James M Farnham, Karl Gerhard Blaasaas, Øyvind Naess, Lisa A Cannon-Albright

Institute of Health and Society, University of Oslo, P.O Box 1130 Blindervn, 0318, Oslo, Norway., Department of Oncology, University Hospital of North, Norway, Tromsø., Department of Biostatistics, Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Norway., Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Finance Norway, P.O Box 2473 Solli, 0202, Oslo, Norway.

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